Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery

Recent advances in metabolomic and genome mining approaches have uncovered a poorly understood metabolome that originates solely or in part from bacterial enzyme sources. Whether living on exposed surfaces or within our intestinal tract, our microbial inhabitants produce a remarkably diverse set of...

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Veröffentlicht in:	The Journal of biological chemistry 2017-05, Vol.292 (21), p.8560-8568
Hauptverfasser:	Brown, J. Mark, Hazen, Stanley L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - etiology Atherosclerosis - microbiology cardiovascular disease Drug Discovery Gastrointestinal Microbiome Humans metabolomics Methylamines - metabolism Methylamines - toxicity Mice microbiome Minireviews
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