Parecoxib Provides Analgesic and Opioid-Sparing Effects Following Major Orthopedic Surgery: A Subset Analysis of a Randomized, Placebo-Controlled Clinical Trial
Introduction Orthopedic surgeries are among the most common and most painful surgeries performed. A multimodal analgesic approach is recommended to reduce opioid consumption, provide effective pain relief, and improve outcomes following surgery. This study examined the efficacy and opioid-sparing ef...
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| Veröffentlicht in: | Pain and therapy 2017-06, Vol.6 (1), p.61-72 |
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| creator | Diaz-Borjon, Efrain Torres-Gomez, Armando Essex, Margaret Noyes Salomon, Patricia Li, Chunming Cheung, Raymond Parsons, Bruce |
| description | Introduction
Orthopedic surgeries are among the most common and most painful surgeries performed. A multimodal analgesic approach is recommended to reduce opioid consumption, provide effective pain relief, and improve outcomes following surgery. This study examined the efficacy and opioid-sparing effects of parecoxib following major orthopedic surgery.
Methods
This subset analysis of a large, multicenter, randomized, double-blind, placebo-controlled study of parecoxib examined treatment effects on postoperative pain severity, pain interference with function, opioid consumption, occurrence of opioid-related symptoms, safety, and patient satisfaction following major orthopedic surgery.
Results
Pain scores were significantly lower in the parecoxib group (
n
= 142) compared with placebo (
n
= 139) on day 2 (−22%;
p
|
| doi_str_mv | 10.1007/s40122-017-0066-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5447543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1874443194</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-3ad4c5bff6d8aac32c8f9130918375f0d37a0330ce1d6b8fa5489d86036e58fe3</originalsourceid><addsrcrecordid>eNp1ktFuFCEUhidGY5vaB_DGkHjjhaMwwAzjhclm01aTmt3YmnhHGDhs2bDDCDPV7dP4qLLu2lQTrziB7_z8cP6ieE7wG4Jx8zYxTKqqxKQpMa7rkj8qjivS0rLm5OvjQy0q2hwVpymtMc644C3jT4ujSlSct5wfFz-XKoIOP1yHljHcOgMJzXrlV5CcRqo3aDG44Ex5Najo-hU6sxb0mNB58D583-18UusQ0SKON2EAk7uupriCuH2HZrnsEoy_FbfJJRQsUuhzlg0bdwfmNVp6paEL5Tz0Y8ySYNDcu95p5dF1dMo_K55Y5ROcHtaT4sv52fX8Q3m5uPg4n12WmjV4LKkyTPPO2toIpTSttLAtobglgjbcYkMbhSnFGoipO2EVZ6I1osa0Bi4s0JPi_V53mLoNGA3Zj_JyiG6j4lYG5eTfJ727katwKzljDWc0C7w6CMTwbYI0yo1LGrxXPYQpSSIaxhglLcvoy3_QdZhi_qNMtdklbXldZ4rsKR1DShHsvRmC5S4Cch8BmSMgdxGQPPe8ePiK-44_A89AtQfSsBsnxAdX_1f1F5-Evp0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1903339566</pqid></control><display><type>article</type><title>Parecoxib Provides Analgesic and Opioid-Sparing Effects Following Major Orthopedic Surgery: A Subset Analysis of a Randomized, Placebo-Controlled Clinical Trial</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature OA Free Journals</source><source>PubMed Central</source><creator>Diaz-Borjon, Efrain ; Torres-Gomez, Armando ; Essex, Margaret Noyes ; Salomon, Patricia ; Li, Chunming ; Cheung, Raymond ; Parsons, Bruce</creator><creatorcontrib>Diaz-Borjon, Efrain ; Torres-Gomez, Armando ; Essex, Margaret Noyes ; Salomon, Patricia ; Li, Chunming ; Cheung, Raymond ; Parsons, Bruce</creatorcontrib><description>Introduction
Orthopedic surgeries are among the most common and most painful surgeries performed. A multimodal analgesic approach is recommended to reduce opioid consumption, provide effective pain relief, and improve outcomes following surgery. This study examined the efficacy and opioid-sparing effects of parecoxib following major orthopedic surgery.
Methods
This subset analysis of a large, multicenter, randomized, double-blind, placebo-controlled study of parecoxib examined treatment effects on postoperative pain severity, pain interference with function, opioid consumption, occurrence of opioid-related symptoms, safety, and patient satisfaction following major orthopedic surgery.
Results
Pain scores were significantly lower in the parecoxib group (
n
= 142) compared with placebo (
n
= 139) on day 2 (−22%;
p
< 0.001) and day 3 (−17%;
p
= 0.004). Pain interference with function scores were also significantly lower in the parecoxib group on day 2 (−32%;
p
< 0.001) and day 3 (−27%;
p
= 0.003) relative to placebo. Additionally, significantly less supplemental morphine was required in the parecoxib group relative to placebo through 24 h (−28%;
p
= 0.008) and 48 h (−33%;
p
< 0.001). Patients in the parecoxib group had a reduced risk of experiencing opioid-related symptoms including fatigue, drowsiness, inability to concentrate, confusion, nausea, constipation, and confusion on day 2 and/or day 3. Finally, more patients receiving parecoxib (42%) rated treatment as “excellent” compared to those receiving placebo (21%).
Conclusions
These findings support the use of parecoxib for the management of pain following major orthopedic surgery.</description><identifier>ISSN: 2193-8237</identifier><identifier>EISSN: 2193-651X</identifier><identifier>DOI: 10.1007/s40122-017-0066-5</identifier><identifier>PMID: 28255955</identifier><language>eng</language><publisher>Cheshire: Springer Healthcare</publisher><subject>Analgesics ; Bone surgery ; Clinical trials ; Evidence-based medicine ; Internal Medicine ; Medicine ; Medicine & Public Health ; Narcotics ; Original Research ; Orthopedics ; Pain ; Pain Medicine ; Patient satisfaction</subject><ispartof>Pain and therapy, 2017-06, Vol.6 (1), p.61-72</ispartof><rights>The Author(s) 2017</rights><rights>Pain and Therapy is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-3ad4c5bff6d8aac32c8f9130918375f0d37a0330ce1d6b8fa5489d86036e58fe3</citedby><cites>FETCH-LOGICAL-c470t-3ad4c5bff6d8aac32c8f9130918375f0d37a0330ce1d6b8fa5489d86036e58fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447543/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447543/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28255955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diaz-Borjon, Efrain</creatorcontrib><creatorcontrib>Torres-Gomez, Armando</creatorcontrib><creatorcontrib>Essex, Margaret Noyes</creatorcontrib><creatorcontrib>Salomon, Patricia</creatorcontrib><creatorcontrib>Li, Chunming</creatorcontrib><creatorcontrib>Cheung, Raymond</creatorcontrib><creatorcontrib>Parsons, Bruce</creatorcontrib><title>Parecoxib Provides Analgesic and Opioid-Sparing Effects Following Major Orthopedic Surgery: A Subset Analysis of a Randomized, Placebo-Controlled Clinical Trial</title><title>Pain and therapy</title><addtitle>Pain Ther</addtitle><addtitle>Pain Ther</addtitle><description>Introduction
Orthopedic surgeries are among the most common and most painful surgeries performed. A multimodal analgesic approach is recommended to reduce opioid consumption, provide effective pain relief, and improve outcomes following surgery. This study examined the efficacy and opioid-sparing effects of parecoxib following major orthopedic surgery.
Methods
This subset analysis of a large, multicenter, randomized, double-blind, placebo-controlled study of parecoxib examined treatment effects on postoperative pain severity, pain interference with function, opioid consumption, occurrence of opioid-related symptoms, safety, and patient satisfaction following major orthopedic surgery.
Results
Pain scores were significantly lower in the parecoxib group (
n
= 142) compared with placebo (
n
= 139) on day 2 (−22%;
p
< 0.001) and day 3 (−17%;
p
= 0.004). Pain interference with function scores were also significantly lower in the parecoxib group on day 2 (−32%;
p
< 0.001) and day 3 (−27%;
p
= 0.003) relative to placebo. Additionally, significantly less supplemental morphine was required in the parecoxib group relative to placebo through 24 h (−28%;
p
= 0.008) and 48 h (−33%;
p
< 0.001). Patients in the parecoxib group had a reduced risk of experiencing opioid-related symptoms including fatigue, drowsiness, inability to concentrate, confusion, nausea, constipation, and confusion on day 2 and/or day 3. Finally, more patients receiving parecoxib (42%) rated treatment as “excellent” compared to those receiving placebo (21%).
Conclusions
These findings support the use of parecoxib for the management of pain following major orthopedic surgery.</description><subject>Analgesics</subject><subject>Bone surgery</subject><subject>Clinical trials</subject><subject>Evidence-based medicine</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Narcotics</subject><subject>Original Research</subject><subject>Orthopedics</subject><subject>Pain</subject><subject>Pain Medicine</subject><subject>Patient satisfaction</subject><issn>2193-8237</issn><issn>2193-651X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1ktFuFCEUhidGY5vaB_DGkHjjhaMwwAzjhclm01aTmt3YmnhHGDhs2bDDCDPV7dP4qLLu2lQTrziB7_z8cP6ieE7wG4Jx8zYxTKqqxKQpMa7rkj8qjivS0rLm5OvjQy0q2hwVpymtMc644C3jT4ujSlSct5wfFz-XKoIOP1yHljHcOgMJzXrlV5CcRqo3aDG44Ex5Najo-hU6sxb0mNB58D583-18UusQ0SKON2EAk7uupriCuH2HZrnsEoy_FbfJJRQsUuhzlg0bdwfmNVp6paEL5Tz0Y8ySYNDcu95p5dF1dMo_K55Y5ROcHtaT4sv52fX8Q3m5uPg4n12WmjV4LKkyTPPO2toIpTSttLAtobglgjbcYkMbhSnFGoipO2EVZ6I1osa0Bi4s0JPi_V53mLoNGA3Zj_JyiG6j4lYG5eTfJ727katwKzljDWc0C7w6CMTwbYI0yo1LGrxXPYQpSSIaxhglLcvoy3_QdZhi_qNMtdklbXldZ4rsKR1DShHsvRmC5S4Cch8BmSMgdxGQPPe8ePiK-44_A89AtQfSsBsnxAdX_1f1F5-Evp0</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Diaz-Borjon, Efrain</creator><creator>Torres-Gomez, Armando</creator><creator>Essex, Margaret Noyes</creator><creator>Salomon, Patricia</creator><creator>Li, Chunming</creator><creator>Cheung, Raymond</creator><creator>Parsons, Bruce</creator><general>Springer Healthcare</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170601</creationdate><title>Parecoxib Provides Analgesic and Opioid-Sparing Effects Following Major Orthopedic Surgery: A Subset Analysis of a Randomized, Placebo-Controlled Clinical Trial</title><author>Diaz-Borjon, Efrain ; Torres-Gomez, Armando ; Essex, Margaret Noyes ; Salomon, Patricia ; Li, Chunming ; Cheung, Raymond ; Parsons, Bruce</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-3ad4c5bff6d8aac32c8f9130918375f0d37a0330ce1d6b8fa5489d86036e58fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Analgesics</topic><topic>Bone surgery</topic><topic>Clinical trials</topic><topic>Evidence-based medicine</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Narcotics</topic><topic>Original Research</topic><topic>Orthopedics</topic><topic>Pain</topic><topic>Pain Medicine</topic><topic>Patient satisfaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diaz-Borjon, Efrain</creatorcontrib><creatorcontrib>Torres-Gomez, Armando</creatorcontrib><creatorcontrib>Essex, Margaret Noyes</creatorcontrib><creatorcontrib>Salomon, Patricia</creatorcontrib><creatorcontrib>Li, Chunming</creatorcontrib><creatorcontrib>Cheung, Raymond</creatorcontrib><creatorcontrib>Parsons, Bruce</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pain and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diaz-Borjon, Efrain</au><au>Torres-Gomez, Armando</au><au>Essex, Margaret Noyes</au><au>Salomon, Patricia</au><au>Li, Chunming</au><au>Cheung, Raymond</au><au>Parsons, Bruce</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parecoxib Provides Analgesic and Opioid-Sparing Effects Following Major Orthopedic Surgery: A Subset Analysis of a Randomized, Placebo-Controlled Clinical Trial</atitle><jtitle>Pain and therapy</jtitle><stitle>Pain Ther</stitle><addtitle>Pain Ther</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>6</volume><issue>1</issue><spage>61</spage><epage>72</epage><pages>61-72</pages><issn>2193-8237</issn><eissn>2193-651X</eissn><abstract>Introduction
Orthopedic surgeries are among the most common and most painful surgeries performed. A multimodal analgesic approach is recommended to reduce opioid consumption, provide effective pain relief, and improve outcomes following surgery. This study examined the efficacy and opioid-sparing effects of parecoxib following major orthopedic surgery.
Methods
This subset analysis of a large, multicenter, randomized, double-blind, placebo-controlled study of parecoxib examined treatment effects on postoperative pain severity, pain interference with function, opioid consumption, occurrence of opioid-related symptoms, safety, and patient satisfaction following major orthopedic surgery.
Results
Pain scores were significantly lower in the parecoxib group (
n
= 142) compared with placebo (
n
= 139) on day 2 (−22%;
p
< 0.001) and day 3 (−17%;
p
= 0.004). Pain interference with function scores were also significantly lower in the parecoxib group on day 2 (−32%;
p
< 0.001) and day 3 (−27%;
p
= 0.003) relative to placebo. Additionally, significantly less supplemental morphine was required in the parecoxib group relative to placebo through 24 h (−28%;
p
= 0.008) and 48 h (−33%;
p
< 0.001). Patients in the parecoxib group had a reduced risk of experiencing opioid-related symptoms including fatigue, drowsiness, inability to concentrate, confusion, nausea, constipation, and confusion on day 2 and/or day 3. Finally, more patients receiving parecoxib (42%) rated treatment as “excellent” compared to those receiving placebo (21%).
Conclusions
These findings support the use of parecoxib for the management of pain following major orthopedic surgery.</abstract><cop>Cheshire</cop><pub>Springer Healthcare</pub><pmid>28255955</pmid><doi>10.1007/s40122-017-0066-5</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pain and therapy, 2017-06, Vol.6 (1), p.61-72 |
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| language | eng |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; PubMed Central |
| subjects | Analgesics Bone surgery Clinical trials Evidence-based medicine Internal Medicine Medicine Medicine & Public Health Narcotics Original Research Orthopedics Pain Pain Medicine Patient satisfaction |
| title | Parecoxib Provides Analgesic and Opioid-Sparing Effects Following Major Orthopedic Surgery: A Subset Analysis of a Randomized, Placebo-Controlled Clinical Trial |
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