Visual evoked potential in RCS rats with Okayama University-type retinal prosthesis (OUReP™) implantation
Photoelectric dye-coupled polyethylene film, designated Okayama University type-retinal prosthesis or OUReP™, generates light-evoked surface electric potentials and stimulates neurons. The dye-coupled films or plain films were implanted subretinally in both eyes of 10 Royal College of Surgeons rats...
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| Veröffentlicht in: | Journal of artificial organs 2017-06, Vol.20 (2), p.158-165 |
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| creator | Alamusi Matsuo, Toshihiko Hosoya, Osamu Uchida, Tetsuya |
| description | Photoelectric dye-coupled polyethylene film, designated Okayama University type-retinal prosthesis or OUReP™, generates light-evoked surface electric potentials and stimulates neurons. The dye-coupled films or plain films were implanted subretinally in both eyes of 10 Royal College of Surgeons rats with hereditary retinal dystrophy at the age of 6 weeks. Visual evoked potentials in response to monocular flashing light stimuli were recorded from cranially-fixed electrodes, 4 weeks and 8 weeks after the implantation. After the recording, subretinal film implantation was confirmed histologically in 7 eyes with dye-coupled films and 7 eyes with plain films. The recordings from these 7 eyes in each group were used for statistical analysis. The amplitudes of visual evoked potentials in the consecutive time points from 125 to 250 ms after flash were significantly larger in the 7 eyes with dye-coupled film implantation, compared to the 7 eyes with plain film implantation at 8 weeks after the implantation (
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| doi_str_mv | 10.1007/s10047-016-0943-4 |
| format | Article |
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P
< 0.05, repeated-measure ANOVA). The photoelectric dye-coupled polyethylene film, as retinal prosthesis, gave rise to visual evoked potential in response to flashing light.</description><identifier>ISSN: 1434-7229</identifier><identifier>EISSN: 1619-0904</identifier><identifier>DOI: 10.1007/s10047-016-0943-4</identifier><identifier>PMID: 28181076</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Aniline Compounds ; Animals ; Biomedical Engineering and Bioengineering ; Cardiac Surgery ; Disease Models, Animal ; Dyes ; Dystrophy ; Evoked potentials ; Evoked Potentials, Visual - physiology ; Eye (anatomy) ; Flashing ; Implantation ; Medical personnel ; Medicine ; Medicine & Public Health ; Nephrology ; Original ; Original Article ; Photoelectricity ; Polyethylene ; Polyethylene films ; Prostheses ; Prosthesis Implantation ; Rats ; Retina ; Retinal degeneration ; Retinal Dystrophies - physiopathology ; Retinal Dystrophies - therapy ; Statistical analysis ; Thiazoles ; Variance analysis ; Visual evoked potentials ; Visual Prosthesis ; Visual stimuli</subject><ispartof>Journal of artificial organs, 2017-06, Vol.20 (2), p.158-165</ispartof><rights>The Author(s) 2017</rights><rights>Journal of Artificial Organs is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-655248256b7aaf6c3093f75641aa3359cdc2713de4fbf5987f4e28083d23980b3</citedby><cites>FETCH-LOGICAL-c494t-655248256b7aaf6c3093f75641aa3359cdc2713de4fbf5987f4e28083d23980b3</cites><orcidid>0000-0001-6570-0030</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10047-016-0943-4$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10047-016-0943-4$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28181076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alamusi</creatorcontrib><creatorcontrib>Matsuo, Toshihiko</creatorcontrib><creatorcontrib>Hosoya, Osamu</creatorcontrib><creatorcontrib>Uchida, Tetsuya</creatorcontrib><title>Visual evoked potential in RCS rats with Okayama University-type retinal prosthesis (OUReP™) implantation</title><title>Journal of artificial organs</title><addtitle>J Artif Organs</addtitle><addtitle>J Artif Organs</addtitle><description>Photoelectric dye-coupled polyethylene film, designated Okayama University type-retinal prosthesis or OUReP™, generates light-evoked surface electric potentials and stimulates neurons. The dye-coupled films or plain films were implanted subretinally in both eyes of 10 Royal College of Surgeons rats with hereditary retinal dystrophy at the age of 6 weeks. Visual evoked potentials in response to monocular flashing light stimuli were recorded from cranially-fixed electrodes, 4 weeks and 8 weeks after the implantation. After the recording, subretinal film implantation was confirmed histologically in 7 eyes with dye-coupled films and 7 eyes with plain films. The recordings from these 7 eyes in each group were used for statistical analysis. The amplitudes of visual evoked potentials in the consecutive time points from 125 to 250 ms after flash were significantly larger in the 7 eyes with dye-coupled film implantation, compared to the 7 eyes with plain film implantation at 8 weeks after the implantation (
P
< 0.05, repeated-measure ANOVA). The photoelectric dye-coupled polyethylene film, as retinal prosthesis, gave rise to visual evoked potential in response to flashing light.</description><subject>Aniline Compounds</subject><subject>Animals</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Cardiac Surgery</subject><subject>Disease Models, Animal</subject><subject>Dyes</subject><subject>Dystrophy</subject><subject>Evoked potentials</subject><subject>Evoked Potentials, Visual - physiology</subject><subject>Eye (anatomy)</subject><subject>Flashing</subject><subject>Implantation</subject><subject>Medical personnel</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Original</subject><subject>Original Article</subject><subject>Photoelectricity</subject><subject>Polyethylene</subject><subject>Polyethylene films</subject><subject>Prostheses</subject><subject>Prosthesis Implantation</subject><subject>Rats</subject><subject>Retina</subject><subject>Retinal degeneration</subject><subject>Retinal Dystrophies - physiopathology</subject><subject>Retinal Dystrophies - therapy</subject><subject>Statistical analysis</subject><subject>Thiazoles</subject><subject>Variance analysis</subject><subject>Visual evoked potentials</subject><subject>Visual Prosthesis</subject><subject>Visual stimuli</subject><issn>1434-7229</issn><issn>1619-0904</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kd1OFDEUxxsDEUQfwBvThBu4GOz3xw2J2QiakKxB19umO9Nhy85Mx7azZu99Eh7NJ7FkkSCJN21Pz-_823P-ALzF6AwjJN-nsjJZISwqpBmt2AtwiAXWJUJsr5wZZZUkRB-AVyndIoQll-glOCAKK4ykOATr7z5NtoNuE9augWPIbsi-XPgBXs--wmhzgj99XsH52m5tb-Fi8BsXk8_bKm9HB6PLfigFYwwpr1zyCZ7MF9fuy-9fd6fQ92Nnh2yzD8NrsN_aLrk3D_sRWFx8_Db7VF3NLz_PPlxVNdMsV4JzwhThYimtbUVNkaat5IJhaynlum5qIjFtHGuXLddKtswRhRRtCNUKLekRON_pjtOyd01dOoq2M2P0vY1bE6w3_2YGvzI3YWM4Y0IxUQROHgRi-DG5lE3vU-260okLUzJYCSE0Z5wX9PgZehumWOZRKI2IIpRzVCi8o-oypBRd-_gZjMy9lWZnpSlWmnsrDSs175528Vjx17sCkB2QSmq4cfHJ0_9V_QN7DqsX</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Alamusi</creator><creator>Matsuo, Toshihiko</creator><creator>Hosoya, Osamu</creator><creator>Uchida, Tetsuya</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6570-0030</orcidid></search><sort><creationdate>20170601</creationdate><title>Visual evoked potential in RCS rats with Okayama University-type retinal prosthesis (OUReP™) implantation</title><author>Alamusi ; Matsuo, Toshihiko ; Hosoya, Osamu ; Uchida, Tetsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-655248256b7aaf6c3093f75641aa3359cdc2713de4fbf5987f4e28083d23980b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aniline Compounds</topic><topic>Animals</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Cardiac Surgery</topic><topic>Disease Models, Animal</topic><topic>Dyes</topic><topic>Dystrophy</topic><topic>Evoked potentials</topic><topic>Evoked Potentials, Visual - physiology</topic><topic>Eye (anatomy)</topic><topic>Flashing</topic><topic>Implantation</topic><topic>Medical personnel</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Original</topic><topic>Original Article</topic><topic>Photoelectricity</topic><topic>Polyethylene</topic><topic>Polyethylene films</topic><topic>Prostheses</topic><topic>Prosthesis Implantation</topic><topic>Rats</topic><topic>Retina</topic><topic>Retinal degeneration</topic><topic>Retinal Dystrophies - physiopathology</topic><topic>Retinal Dystrophies - therapy</topic><topic>Statistical analysis</topic><topic>Thiazoles</topic><topic>Variance analysis</topic><topic>Visual evoked potentials</topic><topic>Visual Prosthesis</topic><topic>Visual stimuli</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alamusi</creatorcontrib><creatorcontrib>Matsuo, Toshihiko</creatorcontrib><creatorcontrib>Hosoya, Osamu</creatorcontrib><creatorcontrib>Uchida, Tetsuya</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alamusi</au><au>Matsuo, Toshihiko</au><au>Hosoya, Osamu</au><au>Uchida, Tetsuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visual evoked potential in RCS rats with Okayama University-type retinal prosthesis (OUReP™) implantation</atitle><jtitle>Journal of artificial organs</jtitle><stitle>J Artif Organs</stitle><addtitle>J Artif Organs</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>20</volume><issue>2</issue><spage>158</spage><epage>165</epage><pages>158-165</pages><issn>1434-7229</issn><eissn>1619-0904</eissn><abstract>Photoelectric dye-coupled polyethylene film, designated Okayama University type-retinal prosthesis or OUReP™, generates light-evoked surface electric potentials and stimulates neurons. The dye-coupled films or plain films were implanted subretinally in both eyes of 10 Royal College of Surgeons rats with hereditary retinal dystrophy at the age of 6 weeks. Visual evoked potentials in response to monocular flashing light stimuli were recorded from cranially-fixed electrodes, 4 weeks and 8 weeks after the implantation. After the recording, subretinal film implantation was confirmed histologically in 7 eyes with dye-coupled films and 7 eyes with plain films. The recordings from these 7 eyes in each group were used for statistical analysis. The amplitudes of visual evoked potentials in the consecutive time points from 125 to 250 ms after flash were significantly larger in the 7 eyes with dye-coupled film implantation, compared to the 7 eyes with plain film implantation at 8 weeks after the implantation (
P
< 0.05, repeated-measure ANOVA). The photoelectric dye-coupled polyethylene film, as retinal prosthesis, gave rise to visual evoked potential in response to flashing light.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>28181076</pmid><doi>10.1007/s10047-016-0943-4</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6570-0030</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aniline Compounds Animals Biomedical Engineering and Bioengineering Cardiac Surgery Disease Models, Animal Dyes Dystrophy Evoked potentials Evoked Potentials, Visual - physiology Eye (anatomy) Flashing Implantation Medical personnel Medicine Medicine & Public Health Nephrology Original Original Article Photoelectricity Polyethylene Polyethylene films Prostheses Prosthesis Implantation Rats Retina Retinal degeneration Retinal Dystrophies - physiopathology Retinal Dystrophies - therapy Statistical analysis Thiazoles Variance analysis Visual evoked potentials Visual Prosthesis Visual stimuli |
| title | Visual evoked potential in RCS rats with Okayama University-type retinal prosthesis (OUReP™) implantation |
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