Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining

•Human Polλ is efficiently phosphorylated by DNA-PKcs in vitro and predominantly by ATM after IR-mediated DSBs in vivo.•Polλ Thr204 is the main target for ATM- and DNA-PKcs-mediated phosphorylation.•Phosphorylation of Polλ at Thr204 after IR is required for efficient Polλ-mediated gap-filling NHEJ r...

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Veröffentlicht in:DNA repair 2017-03, Vol.51, p.31-45
Hauptverfasser: Sastre-Moreno, Guillermo, Pryor, John M., Moreno-Oñate, Marta, Herrero-Ruiz, Andrés M., Cortés-Ledesma, Felipe, Blanco, Luis, Ramsden, Dale A., Ruiz, Jose F.
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