β‐Elemene Selectively Inhibits the Proliferation of Glioma Stem‐Like Cells Through the Downregulation of Notch1

Glioma is the most frequent primary central nervous system tumor. Although the current first‐line medicine, temozolomide (TMZ), promotes patient survival, drug resistance develops easily. Thus, it is important to investigate novel therapeutic reagents to solidify the treatment effect. β‐Elemene (bEL...

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Veröffentlicht in:	Stem cells translational medicine 2017-03, Vol.6 (3), p.830-839
Hauptverfasser:	Feng, Hai‐bin, Wang, Jing, Jiang, Hao‐ran, Mei, Xin, Zhao, Yi‐ying, Chen, Fu‐rong, Qu, Yue, Sai, Ke, Guo, Cheng‐cheng, Yang, Qun‐ying, Zhang, Zong‐ping, Chen, Zhong‐ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Brain cancer Cancer Cancer Stem Cells Cancer therapies Carcinogenesis - drug effects Carcinogenesis - metabolism Carcinogenesis - pathology Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Central nervous system Disease Models, Animal Down-Regulation - drug effects Drug resistance Drug Synergism Glioma Glioma - pathology Glioma cells Glioma stem‐like cell Grants Growth factors Humans Kinases Male Medical prognosis Mice, Nude Mimicry Molecular modelling Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Patients Proliferation R&D Radiation therapy Receptor, Notch1 - metabolism Research & development Sesquiterpenes - administration & dosage Sesquiterpenes - pharmacology Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism Spheroids, Cellular - pathology Stem cells Temozolomide Temozolomide - administration & dosage Temozolomide - pharmacology Translational s and Reviews Tumorigenesis Xenografts β‐Elemene
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