Histologic tissue response to furcation perforation repair using mineral trioxide aggregate or dental pulp stem cells loaded onto treated dentin matrix or tricalcium phosphate
Objectives The aim of this study is to compare the effect of treated dentine matrix (TDM) and tricalcium phosphate (TCP) scaffolds on odontogenic differentiation and mineralization of dental pulp stem cells (DPSCs) in furcation perforations created in the pulp chamber floor of premolar teeth in dogs...
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| Veröffentlicht in: | Clinical oral investigations 2017-06, Vol.21 (5), p.1579-1588 |
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| creator | Bakhtiar, H Mirzaei, H Bagheri, M R Fani, N Mashhadiabbas, F Baghaban Eslaminejad, M Sharifi, D Nekoofar, M H Dummer, PMH |
| description | Objectives
The aim of this study is to compare the effect of treated dentine matrix (TDM) and tricalcium phosphate (TCP) scaffolds on odontogenic differentiation and mineralization of dental pulp stem cells (DPSCs) in furcation perforations created in the pulp chamber floor of premolar teeth in dogs.
Material and methods
DPSCs were isolated and cultured from the dental pulp of the maxillary left second and third premolars of dogs. The DPSCs were loaded on TCP (SC+TCP) and TDM (SC+TDM) scaffolds and inserted into intentionally perforated pulp chamber floors of premolars in dogs; six teeth were used for each group. Three more groups of six specimens were created, and mineral trioxide aggregate (MTA), TDM, and TCP were inserted into the perforations to act as controls. An intact premolar and no treatment in the perforation site were used as positive and negative controls respectively. After 3 months, the animals were sacrificed and the type of inflammation, presence of dentine, continuation and type of cementum, type of connective tissue, and presence of foreign body reaction were evaluated, and significant differences were between groups determined using the Fisher’s exact test. The evaluation of the amount of inflammation and the percentage of new bone formation was evaluated using the Mann-Whitney
U
test.
Results
The negative control group was associated with severe inflammation and granulation tissue formation. In the positive control group, intact periodontal tissues and no inflammation were observed. Dentine bridge formation was not seen in specimens of any group. The specimens in the SC+TDM group were associated with significantly more bone formation than other groups (
P
|
| doi_str_mv | 10.1007/s00784-016-1967-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5442265</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1835509137</sourcerecordid><originalsourceid>FETCH-LOGICAL-c536t-fa8f90816eae98996adb1b0d3754e5b0309efdb81e3e8ff631e556bb5546401e3</originalsourceid><addsrcrecordid>eNp1kk1v1jAMxysEYmPwAbigSFy4FJKmSZoLEpqAIU3iAucobd0-mdqk5AVtn4qviJ91TAOJS2zFP_9ty66ql4y-ZZSqdwmfrq0pkzXTUtX0UXXKWi5rrhR7fOs3tdQdO6mepXRFKWul4k-rk0YpyaRqTqtfFy7lsITZDSS7lAqQCGkLPgHJgUwlDja74MkGcQpx9yNs1kVSkvMzWZ2HaBeSowvXbgRi5znCbDOQEMkIPmNwK8tGUoaVDLAsiSzBjjCS4LFGjoDweIs6T1aLStfHXLSDXQZXVrIdQtoOiD2vnkx2SfDizp5V3z99_HZ-UV9-_fzl_MNlPQgucz3ZbtK0YxIs6E5racee9XTkSrQgesqphmnsOwYcummSnIEQsu-FaGVL8feser_rbqVfYRywNxzSbNGtNt6YYJ35O-LdwczhpxFt2zRSoMCbO4EYfhRI2awuHYe3HkJJhnVcCKoZV4i-_ge9CiV6HM8wjTtrqJYSKbZTQwwpRZjum2HUHM_B7Odg8BzM8RwMxZxXD6e4z_izfwSaHUgY8jPEB6X_q_obWO_GgQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1901420966</pqid></control><display><type>article</type><title>Histologic tissue response to furcation perforation repair using mineral trioxide aggregate or dental pulp stem cells loaded onto treated dentin matrix or tricalcium phosphate</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Bakhtiar, H ; Mirzaei, H ; Bagheri, M R ; Fani, N ; Mashhadiabbas, F ; Baghaban Eslaminejad, M ; Sharifi, D ; Nekoofar, M H ; Dummer, PMH</creator><creatorcontrib>Bakhtiar, H ; Mirzaei, H ; Bagheri, M R ; Fani, N ; Mashhadiabbas, F ; Baghaban Eslaminejad, M ; Sharifi, D ; Nekoofar, M H ; Dummer, PMH</creatorcontrib><description>Objectives
The aim of this study is to compare the effect of treated dentine matrix (TDM) and tricalcium phosphate (TCP) scaffolds on odontogenic differentiation and mineralization of dental pulp stem cells (DPSCs) in furcation perforations created in the pulp chamber floor of premolar teeth in dogs.
Material and methods
DPSCs were isolated and cultured from the dental pulp of the maxillary left second and third premolars of dogs. The DPSCs were loaded on TCP (SC+TCP) and TDM (SC+TDM) scaffolds and inserted into intentionally perforated pulp chamber floors of premolars in dogs; six teeth were used for each group. Three more groups of six specimens were created, and mineral trioxide aggregate (MTA), TDM, and TCP were inserted into the perforations to act as controls. An intact premolar and no treatment in the perforation site were used as positive and negative controls respectively. After 3 months, the animals were sacrificed and the type of inflammation, presence of dentine, continuation and type of cementum, type of connective tissue, and presence of foreign body reaction were evaluated, and significant differences were between groups determined using the Fisher’s exact test. The evaluation of the amount of inflammation and the percentage of new bone formation was evaluated using the Mann-Whitney
U
test.
Results
The negative control group was associated with severe inflammation and granulation tissue formation. In the positive control group, intact periodontal tissues and no inflammation were observed. Dentine bridge formation was not seen in specimens of any group. The specimens in the SC+TDM group were associated with significantly more bone formation than other groups (
P
< 0.001). The amount of inflammation was less than 10 % in specimens of all groups with the exception of three specimens in the TCP group that were categorized as 10–30 %. Chronic inflammation without foreign body reactions was the major pattern of inflammation in groups. Formation of cementum with a cellular and continuous appearance was seen in all specimens.
Conclusions
SC+TDM was associated with significantly more bone formation when used to repair uninfected furcation perforations in the premolar teeth of dogs.
Clinical relevance
Application of TDM as a biological scaffold in combination with DPSCs may offer an advantage during the repair of root perforation defects.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-016-1967-0</identifier><identifier>PMID: 27761672</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aluminum Compounds - pharmacology ; Animals ; Bone growth ; Calcium Compounds - pharmacology ; Calcium Phosphates - pharmacology ; Cell Differentiation - drug effects ; Cells, Cultured ; Cementum ; Dental pulp ; Dental Pulp - cytology ; Dentin - drug effects ; Dentistry ; Dogs ; Drug Combinations ; Furcation Defects - drug therapy ; Inflammation ; Maxilla ; Medicine ; Mineralization ; Original ; Original Article ; Osteogenesis ; Oxides - pharmacology ; Periodontics ; Premolars ; Silicates - pharmacology ; Stem cell transplantation ; Stem cells ; Teeth ; Tissue Scaffolds ; Tricalcium phosphate</subject><ispartof>Clinical oral investigations, 2017-06, Vol.21 (5), p.1579-1588</ispartof><rights>The Author(s) 2016</rights><rights>Clinical Oral Investigations is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-fa8f90816eae98996adb1b0d3754e5b0309efdb81e3e8ff631e556bb5546401e3</citedby><cites>FETCH-LOGICAL-c536t-fa8f90816eae98996adb1b0d3754e5b0309efdb81e3e8ff631e556bb5546401e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-016-1967-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-016-1967-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27761672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakhtiar, H</creatorcontrib><creatorcontrib>Mirzaei, H</creatorcontrib><creatorcontrib>Bagheri, M R</creatorcontrib><creatorcontrib>Fani, N</creatorcontrib><creatorcontrib>Mashhadiabbas, F</creatorcontrib><creatorcontrib>Baghaban Eslaminejad, M</creatorcontrib><creatorcontrib>Sharifi, D</creatorcontrib><creatorcontrib>Nekoofar, M H</creatorcontrib><creatorcontrib>Dummer, PMH</creatorcontrib><title>Histologic tissue response to furcation perforation repair using mineral trioxide aggregate or dental pulp stem cells loaded onto treated dentin matrix or tricalcium phosphate</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives
The aim of this study is to compare the effect of treated dentine matrix (TDM) and tricalcium phosphate (TCP) scaffolds on odontogenic differentiation and mineralization of dental pulp stem cells (DPSCs) in furcation perforations created in the pulp chamber floor of premolar teeth in dogs.
Material and methods
DPSCs were isolated and cultured from the dental pulp of the maxillary left second and third premolars of dogs. The DPSCs were loaded on TCP (SC+TCP) and TDM (SC+TDM) scaffolds and inserted into intentionally perforated pulp chamber floors of premolars in dogs; six teeth were used for each group. Three more groups of six specimens were created, and mineral trioxide aggregate (MTA), TDM, and TCP were inserted into the perforations to act as controls. An intact premolar and no treatment in the perforation site were used as positive and negative controls respectively. After 3 months, the animals were sacrificed and the type of inflammation, presence of dentine, continuation and type of cementum, type of connective tissue, and presence of foreign body reaction were evaluated, and significant differences were between groups determined using the Fisher’s exact test. The evaluation of the amount of inflammation and the percentage of new bone formation was evaluated using the Mann-Whitney
U
test.
Results
The negative control group was associated with severe inflammation and granulation tissue formation. In the positive control group, intact periodontal tissues and no inflammation were observed. Dentine bridge formation was not seen in specimens of any group. The specimens in the SC+TDM group were associated with significantly more bone formation than other groups (
P
< 0.001). The amount of inflammation was less than 10 % in specimens of all groups with the exception of three specimens in the TCP group that were categorized as 10–30 %. Chronic inflammation without foreign body reactions was the major pattern of inflammation in groups. Formation of cementum with a cellular and continuous appearance was seen in all specimens.
Conclusions
SC+TDM was associated with significantly more bone formation when used to repair uninfected furcation perforations in the premolar teeth of dogs.
Clinical relevance
Application of TDM as a biological scaffold in combination with DPSCs may offer an advantage during the repair of root perforation defects.</description><subject>Aluminum Compounds - pharmacology</subject><subject>Animals</subject><subject>Bone growth</subject><subject>Calcium Compounds - pharmacology</subject><subject>Calcium Phosphates - pharmacology</subject><subject>Cell Differentiation - drug effects</subject><subject>Cells, Cultured</subject><subject>Cementum</subject><subject>Dental pulp</subject><subject>Dental Pulp - cytology</subject><subject>Dentin - drug effects</subject><subject>Dentistry</subject><subject>Dogs</subject><subject>Drug Combinations</subject><subject>Furcation Defects - drug therapy</subject><subject>Inflammation</subject><subject>Maxilla</subject><subject>Medicine</subject><subject>Mineralization</subject><subject>Original</subject><subject>Original Article</subject><subject>Osteogenesis</subject><subject>Oxides - pharmacology</subject><subject>Periodontics</subject><subject>Premolars</subject><subject>Silicates - pharmacology</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Teeth</subject><subject>Tissue Scaffolds</subject><subject>Tricalcium phosphate</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kk1v1jAMxysEYmPwAbigSFy4FJKmSZoLEpqAIU3iAucobd0-mdqk5AVtn4qviJ91TAOJS2zFP_9ty66ql4y-ZZSqdwmfrq0pkzXTUtX0UXXKWi5rrhR7fOs3tdQdO6mepXRFKWul4k-rk0YpyaRqTqtfFy7lsITZDSS7lAqQCGkLPgHJgUwlDja74MkGcQpx9yNs1kVSkvMzWZ2HaBeSowvXbgRi5znCbDOQEMkIPmNwK8tGUoaVDLAsiSzBjjCS4LFGjoDweIs6T1aLStfHXLSDXQZXVrIdQtoOiD2vnkx2SfDizp5V3z99_HZ-UV9-_fzl_MNlPQgucz3ZbtK0YxIs6E5racee9XTkSrQgesqphmnsOwYcummSnIEQsu-FaGVL8feser_rbqVfYRywNxzSbNGtNt6YYJ35O-LdwczhpxFt2zRSoMCbO4EYfhRI2awuHYe3HkJJhnVcCKoZV4i-_ge9CiV6HM8wjTtrqJYSKbZTQwwpRZjum2HUHM_B7Odg8BzM8RwMxZxXD6e4z_izfwSaHUgY8jPEB6X_q_obWO_GgQ</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Bakhtiar, H</creator><creator>Mirzaei, H</creator><creator>Bagheri, M R</creator><creator>Fani, N</creator><creator>Mashhadiabbas, F</creator><creator>Baghaban Eslaminejad, M</creator><creator>Sharifi, D</creator><creator>Nekoofar, M H</creator><creator>Dummer, PMH</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170601</creationdate><title>Histologic tissue response to furcation perforation repair using mineral trioxide aggregate or dental pulp stem cells loaded onto treated dentin matrix or tricalcium phosphate</title><author>Bakhtiar, H ; Mirzaei, H ; Bagheri, M R ; Fani, N ; Mashhadiabbas, F ; Baghaban Eslaminejad, M ; Sharifi, D ; Nekoofar, M H ; Dummer, PMH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-fa8f90816eae98996adb1b0d3754e5b0309efdb81e3e8ff631e556bb5546401e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aluminum Compounds - pharmacology</topic><topic>Animals</topic><topic>Bone growth</topic><topic>Calcium Compounds - pharmacology</topic><topic>Calcium Phosphates - pharmacology</topic><topic>Cell Differentiation - drug effects</topic><topic>Cells, Cultured</topic><topic>Cementum</topic><topic>Dental pulp</topic><topic>Dental Pulp - cytology</topic><topic>Dentin - drug effects</topic><topic>Dentistry</topic><topic>Dogs</topic><topic>Drug Combinations</topic><topic>Furcation Defects - drug therapy</topic><topic>Inflammation</topic><topic>Maxilla</topic><topic>Medicine</topic><topic>Mineralization</topic><topic>Original</topic><topic>Original Article</topic><topic>Osteogenesis</topic><topic>Oxides - pharmacology</topic><topic>Periodontics</topic><topic>Premolars</topic><topic>Silicates - pharmacology</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Teeth</topic><topic>Tissue Scaffolds</topic><topic>Tricalcium phosphate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakhtiar, H</creatorcontrib><creatorcontrib>Mirzaei, H</creatorcontrib><creatorcontrib>Bagheri, M R</creatorcontrib><creatorcontrib>Fani, N</creatorcontrib><creatorcontrib>Mashhadiabbas, F</creatorcontrib><creatorcontrib>Baghaban Eslaminejad, M</creatorcontrib><creatorcontrib>Sharifi, D</creatorcontrib><creatorcontrib>Nekoofar, M H</creatorcontrib><creatorcontrib>Dummer, PMH</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakhtiar, H</au><au>Mirzaei, H</au><au>Bagheri, M R</au><au>Fani, N</au><au>Mashhadiabbas, F</au><au>Baghaban Eslaminejad, M</au><au>Sharifi, D</au><au>Nekoofar, M H</au><au>Dummer, PMH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histologic tissue response to furcation perforation repair using mineral trioxide aggregate or dental pulp stem cells loaded onto treated dentin matrix or tricalcium phosphate</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>21</volume><issue>5</issue><spage>1579</spage><epage>1588</epage><pages>1579-1588</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives
The aim of this study is to compare the effect of treated dentine matrix (TDM) and tricalcium phosphate (TCP) scaffolds on odontogenic differentiation and mineralization of dental pulp stem cells (DPSCs) in furcation perforations created in the pulp chamber floor of premolar teeth in dogs.
Material and methods
DPSCs were isolated and cultured from the dental pulp of the maxillary left second and third premolars of dogs. The DPSCs were loaded on TCP (SC+TCP) and TDM (SC+TDM) scaffolds and inserted into intentionally perforated pulp chamber floors of premolars in dogs; six teeth were used for each group. Three more groups of six specimens were created, and mineral trioxide aggregate (MTA), TDM, and TCP were inserted into the perforations to act as controls. An intact premolar and no treatment in the perforation site were used as positive and negative controls respectively. After 3 months, the animals were sacrificed and the type of inflammation, presence of dentine, continuation and type of cementum, type of connective tissue, and presence of foreign body reaction were evaluated, and significant differences were between groups determined using the Fisher’s exact test. The evaluation of the amount of inflammation and the percentage of new bone formation was evaluated using the Mann-Whitney
U
test.
Results
The negative control group was associated with severe inflammation and granulation tissue formation. In the positive control group, intact periodontal tissues and no inflammation were observed. Dentine bridge formation was not seen in specimens of any group. The specimens in the SC+TDM group were associated with significantly more bone formation than other groups (
P
< 0.001). The amount of inflammation was less than 10 % in specimens of all groups with the exception of three specimens in the TCP group that were categorized as 10–30 %. Chronic inflammation without foreign body reactions was the major pattern of inflammation in groups. Formation of cementum with a cellular and continuous appearance was seen in all specimens.
Conclusions
SC+TDM was associated with significantly more bone formation when used to repair uninfected furcation perforations in the premolar teeth of dogs.
Clinical relevance
Application of TDM as a biological scaffold in combination with DPSCs may offer an advantage during the repair of root perforation defects.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27761672</pmid><doi>10.1007/s00784-016-1967-0</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1432-6981 |
| ispartof | Clinical oral investigations, 2017-06, Vol.21 (5), p.1579-1588 |
| issn | 1432-6981 1436-3771 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aluminum Compounds - pharmacology Animals Bone growth Calcium Compounds - pharmacology Calcium Phosphates - pharmacology Cell Differentiation - drug effects Cells, Cultured Cementum Dental pulp Dental Pulp - cytology Dentin - drug effects Dentistry Dogs Drug Combinations Furcation Defects - drug therapy Inflammation Maxilla Medicine Mineralization Original Original Article Osteogenesis Oxides - pharmacology Periodontics Premolars Silicates - pharmacology Stem cell transplantation Stem cells Teeth Tissue Scaffolds Tricalcium phosphate |
| title | Histologic tissue response to furcation perforation repair using mineral trioxide aggregate or dental pulp stem cells loaded onto treated dentin matrix or tricalcium phosphate |
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