Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer

Low molecular weight cyclin E (LMW-E) detected by Western blot analysis predicts for reduced breast cancer survival; however, it is impractical for clinical use. LMW-E lacks a nuclear localization signal that leads to accumulation in the cytoplasm that can be detected by IHC. We tested the hypothesi...

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Veröffentlicht in:	Clinical cancer research 2017-06, Vol.23 (12), p.2991-3002
Hauptverfasser:	Hunt, Kelly K, Karakas, Cansu, Ha, Min Jin, Biernacka, Anna, Yi, Min, Sahin, Aysegul A, Adjapong, Opoku, Hortobagyi, Gabriel N, Bondy, Melissa, Thompson, Patricia, Cheung, Kwok Leung, Ellis, Ian O, Bacus, Sarah, Symmans, W Fraser, Do, Kim-Anh, Keyomarsi, Khandan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Biomarkers, Tumor - isolation & purification Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cell Line, Tumor Cell Nucleus - genetics Cyclin E Cyclin E - genetics Cyclin E - isolation & purification Cyclin-dependent kinases Cytoplasm Cytoplasm - genetics Disease-Free Survival Estrogens Experimental design Female Humans Isoforms Localization Low molecular weights Medical prognosis Middle Aged Molecular Weight Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Patients Prognosis Protein Isoforms - genetics Protein Isoforms - isolation & purification Staining Weight reduction
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