Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients

Exhausted T cells in chronic infections and cancer have sustained expression of the inhibitory receptor programmed cell death 1 (PD-1). Therapies that block the PD-1 pathway have shown promising clinical results in a significant number of advanced-stage cancer patients. Nonetheless, a better underst...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-05, Vol.114 (19), p.4993-4998
Hauptverfasser:	Kamphorst, Alice O., Pillai, Rathi N., Yang, Shu, Nasti, Tahseen H., Akondy, Rama S., Wieland, Andreas, Sica, Gabriel L., Yu, Ke, Koenig, Lydia, Patel, Nikita T., Behera, Madhusmita, Wu, Hong, McCausland, Megan, Chen, Zhengjia, Zhang, Chao, Khuri, Fadlo R., Owonikoko, Taofeek K., Ahmed, Rafi, Ramalingam, Suresh S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal, Humanized - administration & dosage Apoptosis Bcl protein Bcl-2 protein Biological Sciences Biomarkers Blood Cancer Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - pathology CD27 antigen CD28 antigen CD38 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell activation Cell death Cell proliferation Cell Proliferation - drug effects CTLA-4 protein Effector cells Female Histocompatibility antigen HLA Humans Immunology Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - immunology Lung Neoplasms - pathology Lymphocyte Activation - drug effects Lymphocytes Lymphocytes T Male Molecules Non-small cell lung carcinoma Patients PD-1 protein Peripheral blood Programmed Cell Death 1 Receptor - antagonists & inhibitors T cell receptors Therapy Tumors
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