Structure of a protective epitope of group B Streptococcus type III capsular polysaccharide

Despite substantial progress in the prevention of group B Streptococcus (GBS) disease with the introduction of intrapartum antibiotic prophylaxis, this pathogen remains a leading cause of neonatal infection. Capsular polysaccharide conjugate vaccines have been tested in phase I/II clinical studies,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-05, Vol.114 (19), p.5017-5022
Hauptverfasser:	Carboni, Filippo, Adamo, Roberto, Fabbrini, Monica, De Ricco, Riccardo, Cattaneo, Vittorio, Brogioni, Barbara, Veggi, Daniele, Pinto, Vittoria, Passalacqua, Irene, Oldrini, Davide, Rappuoli, Rino, Malito, Enrico, Margarit, Immaculada y Ros, Berti, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antibiotics Antibodies Antigens Atomic structure Biological Sciences Carbohydrates Crystal structure Crystallography Depolymerization Epitope mapping Galactose Infections Molecular structure Monoclonal antibodies Neonates NMR Nuclear magnetic resonance Oligosaccharides Prophylaxis Protective structures Recognition Saturation Streptococcus Streptococcus infections Sugar Vaccines X-ray crystallography
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