Fluorination at the 4 position alters the substrate behavior of l-glutamine and l-glutamate: Implications for positron emission tomography of neoplasias

Metabolism of the 2S,4S- and 2S,4R diastereoisomers of 4-FGln and 4-FGln. The solid arrows indicate the proposed metabolic pathways for the 2S,4S- and 2S,4R diastereoisomers of 4-FGln and 4F-Glu, while the broken arrows indicate the less favored pathways. [Display omitted] •Activity with glutamine t...

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Veröffentlicht in:	Journal of fluorine chemistry 2016-12, Vol.192 (A), p.58-67
Hauptverfasser:	Jeitner, Thomas M., Kristoferson, Eva, Azcona, Juan A., Pinto, John T., Stalnecker, Clint, Erickson, Jon W., Kung, Hank F., Li, Jianyong, Ploessl, Karl, Cooper, Arthur J.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Fluoroglutamate Fluoroglutamine Glutamate-utilizing enzymes Glutamine-utilizing enzymes
Online-Zugang:	Volltext
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