SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis
The HDL receptor scavenger receptor class B type I (SR-BI) plays crucial roles in cholesterol homeostasis, lipoprotein metabolism, and atherosclerosis. Hepatic SR-BI mediates reverse cholesterol transport (RCT) by the uptake of HDL cholesterol for routing to the bile. Through the selective uptake of...
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| Veröffentlicht in: | Trends in endocrinology and metabolism 2017-06, Vol.28 (6), p.461-472 |
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| creator | Linton, MacRae F Tao, Huan Linton, Edward F Yancey, Patricia G |
| description | The HDL receptor scavenger receptor class B type I (SR-BI) plays crucial roles in cholesterol homeostasis, lipoprotein metabolism, and atherosclerosis. Hepatic SR-BI mediates reverse cholesterol transport (RCT) by the uptake of HDL cholesterol for routing to the bile. Through the selective uptake of HDL lipids, hepatic SR-BI modulates HDL composition and preserves HDL’s atheroprotective functions of mediating cholesterol efflux and minimizing inflammation and oxidation. Macrophage and endothelial cell SR-BI inhibits the development of atherosclerosis by mediating cholesterol trafficking to minimize atherosclerotic lesion foam cell formation. SR-BI signaling also helps limit inflammation and cell death and mediates efferocytosis of apoptotic cells in atherosclerotic lesions thereby preventing vulnerable plaque formation. SR-BI is emerging as a multifunctional therapeutic target to reduce atherosclerosis development. |
| doi_str_mv | 10.1016/j.tem.2017.02.001 |
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Hepatic SR-BI mediates reverse cholesterol transport (RCT) by the uptake of HDL cholesterol for routing to the bile. Through the selective uptake of HDL lipids, hepatic SR-BI modulates HDL composition and preserves HDL’s atheroprotective functions of mediating cholesterol efflux and minimizing inflammation and oxidation. Macrophage and endothelial cell SR-BI inhibits the development of atherosclerosis by mediating cholesterol trafficking to minimize atherosclerotic lesion foam cell formation. SR-BI signaling also helps limit inflammation and cell death and mediates efferocytosis of apoptotic cells in atherosclerotic lesions thereby preventing vulnerable plaque formation. 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| ispartof | Trends in endocrinology and metabolism, 2017-06, Vol.28 (6), p.461-472 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Atherosclerosis - metabolism Biological Transport Cholesterol - metabolism Endocrinology & Metabolism Endothelial Cells - metabolism Humans Macrophages - metabolism |
| title | SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis |
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