Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4

High-affinity and selective antagonists that are able to block the actions of both endogenous and synthetic agonists of G protein–coupled receptors are integral to analysis of receptor function and to support suggestions of therapeutic potential. Although there is great interest in the potential of...

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Veröffentlicht in:	Molecular pharmacology 2017-06, Vol.91 (6), p.630-641
Hauptverfasser:	Watterson, Kenneth R., Hansen, Steffen V.F., Hudson, Brian D., Alvarez-Curto, Elisa, Raihan, Sheikh Zahir, Azevedo, Carlos M.G., Martin, Gabriel, Dunlop, Julia, Yarwood, Stephen J., Ulven, Trond, Milligan, Graeme
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation - drug effects Allosteric Regulation - physiology Animals Biphenyl Compounds - pharmacology Cell Line, Tumor Dose-Response Relationship, Drug HEK293 Cells Humans Mice, Inbred C3H Phenylpropionates - pharmacology Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - physiology
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