MicroRNA-497 suppresses renal cell carcinoma by targeting VEGFR-2 in ACHN cells

Abnormal expression of miRNAs contributed to cancers through regulation of proliferation, apoptosis and drug resistance of cancer cells. The present study was designed to investigate the effect of on renal cell carcinoma (RCC) and its possible mechanism. Forty paired clear cell RCC (ccRCC) tissues a...

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Veröffentlicht in:	Bioscience reports 2017-06, Vol.37 (3)
Hauptverfasser:	Pengcheng, Sun, Ziqi, Wang, Luyao, Yin, Xiangwei, Zhu, Liang, Liu, Yuwei, Liu, Lechen, Li, Wanhai, Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Analysis of Variance Apoptosis Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell Count Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival Down-Regulation Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Humans Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology MAP Kinase Signaling System - genetics MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Neoplasm Invasiveness p38 Mitogen-Activated Protein Kinases - genetics Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism
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