Lupus and proliferative nephritis are PAD4 independent in murine models

Though recent reports suggest that neutrophil extracellular traps (NETs) are a source of antigenic nucleic acids in systemic lupus erythematosus (SLE), we recently showed that inhibition of NETs by targeting the NADPH oxidase complex via cytochrome b-245, β polypeptide (cybb) deletion exacerbated di...

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Veröffentlicht in:JCI insight 2017-05, Vol.2 (10)
Hauptverfasser: Gordon, Rachael A, Herter, Jan M, Rosetti, Florencia, Campbell, Allison M, Nishi, Hiroshi, Kashgarian, Michael, Bastacky, Sheldon I, Marinov, Anthony, Nickerson, Kevin M, Mayadas, Tanya N, Shlomchik, Mark J
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Sprache:eng
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