Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity

Post-translational modification by SUMO (small ubiquitin-like modifier) plays important but still poorly understood regulatory roles in eukaryotic cells, including as a signal for ubiquitination by SUMO targeted ubiquitin ligases (STUbLs). Here, we delineate the molecular mechanisms for SUMO-depende...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genes & development 2017-04, Vol.31 (8), p.802-815
Hauptverfasser:	Liang, Jason, Singh, Namit, Carlson, Christopher R, Albuquerque, Claudio P, Corbett, Kevin D, Zhou, Huilin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs BASIC BIOLOGICAL SCIENCES Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Nucleolus - metabolism cohibin Crystallization desumoylation DNA, Ribosomal - metabolism Endopeptidases - chemistry Endopeptidases - genetics Endopeptidases - metabolism Gene Silencing Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - metabolism Models, Molecular monopolin Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Protein Stability Protein Structure, Quaternary Proteolysis rDNA silencing RENT complex Research Paper Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Small Ubiquitin-Related Modifier Proteins - chemistry Small Ubiquitin-Related Modifier Proteins - metabolism STUbl Sumoylation Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!