Adipocytes enhance murine pancreatic cancer growth via a hepatocyte growth factor (HGF)-mediated mechanism

Abstract Introduction Obesity accelerates the development and progression of pancreatic cancer, though the mechanisms underlying this association are unclear. Adipocytes are biologically active, producing factors such as hepatocyte growth factor (HGF) that may influence tumor progression. We therefo...

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Veröffentlicht in:	International journal of surgery (London, England) England), 2016-04, Vol.28, p.179-184
Hauptverfasser:	Ziegler, Kathryn M, Considine, Robert V, True, Eben, Swartz-Basile, Deborah A, Pitt, Henry A, Zyromski, Nicholas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - physiology Animals Cell Line, Tumor Cell Proliferation Hepatocyte growth factor Hepatocyte Growth Factor - physiology Humans Mice Obesity Pancreatic cancer Pancreatic Neoplasms - pathology Proto-Oncogene Proteins c-met - antagonists & inhibitors Surgery
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