IL‐18‐dependent NKG2D ligand upregulation on accessory cells is mediated by the PI3K/GSK‐3 pathway

IL18‐dependent Rae‐1 upregulation on accessory cells is mediated by the MyD88‐PI3K‐GSK3 pathway, providing important insights into the design of effective NK cell‐based immunotherapies. NK cells are critical for the control of viral infections. Studies have shown that efficient NK cell activation in...

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Veröffentlicht in:	Journal of leukocyte biology 2017-06, Vol.101 (6), p.1317-1323
Hauptverfasser:	Brandstadter, Joshua D., Chen, Huiyao, Jiang, Songfu, Huang, Xiaopei, Yang, Yiping
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Animals Antigen-presenting cells Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism Cell activation Cells, Cultured Control Female Gene Expression Regulation Glycogen Synthase Kinase 3 - metabolism Immunotherapy Infections Inhibition Interleukin 1 Interleukin 18 Interleukin 18 receptors Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Ligands Lymphocyte Activation Macrophages Macrophages, Peritoneal - cytology Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout MyD88 protein Myeloid Differentiation Factor 88 - physiology Natural killer cells NK Cell Lectin-Like Receptor Subfamily K - metabolism NK cells NKG2 antigen Phosphatidylinositol 3-Kinases - metabolism Rae‐1 Receptors, Interleukin-18 - physiology Receptors, Signal Transduction, & Genes Signal transduction Signaling Up-regulation Vaccinia virus Viral infections
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