Human Abuse Potential of an Abuse-Deterrent (AD), Extended-Release (ER) Morphine Product Candidate (Morphine-ADER Injection-Molded Tablets) versus Extended-Release Morphine Administered Orally in Nondependent Recreational Opioid Users

Objective. To compare the relative human abuse potential of intact and manipulated morphine abuse-deterrent, extended-release injection-molded tablets (morphine-ADER-IMT) with that of marketed morphine sulfate ER tablets Methods. This randomized, double-blind, triple-dummy, active- and placebo-contr...

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Veröffentlicht in:	Pain medicine (Malden, Mass.) Mass.), 2017-05, Vol.18 (5), p.898-907
Hauptverfasser:	Smith, Michael D., Webster, Lynn R., Lawler, John, Lindhardt, Karsten, Dayno, Jeffrey M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analgesics, Opioid - administration & dosage Chewing Delayed-Action Preparations - administration & dosage Double-Blind Method Drug abuse Drug Administration Schedule Female Humans Injection Male Morphine Morphine - administration & dosage Narcotics Opioid-Related Disorders - epidemiology Opioids OPIOIDS, SUBSTANCE ABUSE & ADDICTIONS SECTION Oxycodone - administration & dosage Pennsylvania - epidemiology Pharmacodynamics Placebo Effect Prevalence Risk Factors Street Drugs Substance-Related Disorders - epidemiology Sulfates Tablets Treatment Outcome Young Adult
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