DNA methylation epigenotype and clinical features of NRAS‐mutation(+) colorectal cancer

Sporadic colorectal cancer (CRC) is classified into several molecular subtypes. We previously established two groups of DNA methylation markers through genome‐wide DNA methylation analysis to classify CRC into distinct subgroups: high‐, intermediate‐, and low‐methylation epigenotypes (HME, IME, and...

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Veröffentlicht in:	Cancer medicine (Malden, MA) MA), 2017-05, Vol.6 (5), p.1023-1035
Hauptverfasser:	Takane, Kiyoko, Akagi, Kiwamu, Fukuyo, Masaki, Yagi, Koichi, Takayama, Tadatoshi, Kaneda, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aged, 80 and over BRAF mutation Clinical Cancer Research Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology CpG Islands Deoxyribonucleic acid DNA DNA Methylation Epigenesis, Genetic Female Genes Genomes GTP Phosphohydrolases - genetics Humans KRAS mutation Male Membrane Proteins - genetics Middle Aged Mutation Neoplasm Invasiveness NRAS mutation Original Research Phenotypes Prognosis Proto-Oncogene Proteins p21(ras) - genetics Sequence Analysis, DNA Survival Analysis
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