A family study of complex chromosome rearrangement involving chromosomes 1, 8, and 11 and its reproductive consequences

Complex chromosome translocations are structural chromosomal rearrangements involving three or more chromosomes and more than two breakpoints. A complex chromosome rearrangement was detected in a phenotypically normal female patient that was referred to the hospital for genetic counseling due to rep...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of assisted reproduction and genetics 2017-05, Vol.34 (5), p.659-669
Hauptverfasser: Trpchevska, Natalia, Dimova, Ivanka, Arabadji, Tatyana, Milachich, Tanya, Angelova, Svetlana, Dimitrova, Magdalena, Hristova-Savova, Mariela, Andreeva, Petya, Timeva, Tania, Shterev, Atanas
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 669
container_issue 5
container_start_page 659
container_title Journal of assisted reproduction and genetics
container_volume 34
creator Trpchevska, Natalia
Dimova, Ivanka
Arabadji, Tatyana
Milachich, Tanya
Angelova, Svetlana
Dimitrova, Magdalena
Hristova-Savova, Mariela
Andreeva, Petya
Timeva, Tania
Shterev, Atanas
description Complex chromosome translocations are structural chromosomal rearrangements involving three or more chromosomes and more than two breakpoints. A complex chromosome rearrangement was detected in a phenotypically normal female patient that was referred to the hospital for genetic counseling due to reproductive failure. A cytogenetic evaluation was performed, according to standard method of chromosomal analysis, using G-banding technique. The patient’s karyotype showed a balanced complex chromosome rearrangement (BCCR) involving chromosomes 1, 8, and 11 with three breakpoints 1p31, 8q13, and 11q23. The karyotype designed according to ISCN (2013), is 46,XX,t(1;8;11)(p31;q13;q23) (8qter→8q13::1p31→1qter;8pter→8q13::11q23→11qter;11pter→11q23::1p31→1pter). Additionally, the proband’s mother and brother were tested, resulting in the same exact translocation. In this study, we describe all possible meiotic segregations regarding this translocation, as well as the clinical phenotypes which could arise, if unbalanced products of conception survive. This is a rare case of familial complex chromosome rearrangement, giving a view for its reproductive consequences.
doi_str_mv 10.1007/s10815-017-0893-7
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5427656</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1899708186</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-b5d20bbcbf866d75b8bd80d5dcc2bf319d37fd8672537936e7d3229a6b6e49673</originalsourceid><addsrcrecordid>eNp1UclKBDEUDKK4f4AXCXi1Nctk6Ysg4gaCFz2HbD22dCdj0j06f2_GURkPnurBq6pXvALgCKMzjJA4zxhJzCqERYVkTSuxAXYxE2WgFG2WGTFZoQmXO2Av51eEUC0J3QY7pAAv4l3wfgkb3bfdAuZhdAsYG2hjP-v8B7QvKfYxx97D5HVKOkx978MA2zCP3bwN0zVKhvgUylOog4MYf0E75CKcpehGO7RzX4xD9m-jD9bnA7DV6C77w2_cB883109Xd9XD4-391eVDZScCDZVhjiBjrGkk504wI42TyDFnLTENxbWjonGSC8KoqCn3wlFCas0N95OaC7oPLla-s9H03tmSP-lOzVLb67RQUbfq7ya0L2oa54pNiOCMF4OTb4MUS_Y8qNc4plAyKyzrWpQG5JKFVyybYs7JN78XMFLLrtSqK1W6Usuu1DLa8Xq0X8VPOYVAVoRcVuX5ae30v66fbbGhuA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1899708186</pqid></control><display><type>article</type><title>A family study of complex chromosome rearrangement involving chromosomes 1, 8, and 11 and its reproductive consequences</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Trpchevska, Natalia ; Dimova, Ivanka ; Arabadji, Tatyana ; Milachich, Tanya ; Angelova, Svetlana ; Dimitrova, Magdalena ; Hristova-Savova, Mariela ; Andreeva, Petya ; Timeva, Tania ; Shterev, Atanas</creator><creatorcontrib>Trpchevska, Natalia ; Dimova, Ivanka ; Arabadji, Tatyana ; Milachich, Tanya ; Angelova, Svetlana ; Dimitrova, Magdalena ; Hristova-Savova, Mariela ; Andreeva, Petya ; Timeva, Tania ; Shterev, Atanas</creatorcontrib><description>Complex chromosome translocations are structural chromosomal rearrangements involving three or more chromosomes and more than two breakpoints. A complex chromosome rearrangement was detected in a phenotypically normal female patient that was referred to the hospital for genetic counseling due to reproductive failure. A cytogenetic evaluation was performed, according to standard method of chromosomal analysis, using G-banding technique. The patient’s karyotype showed a balanced complex chromosome rearrangement (BCCR) involving chromosomes 1, 8, and 11 with three breakpoints 1p31, 8q13, and 11q23. The karyotype designed according to ISCN (2013), is 46,XX,t(1;8;11)(p31;q13;q23) (8qter→8q13::1p31→1qter;8pter→8q13::11q23→11qter;11pter→11q23::1p31→1pter). Additionally, the proband’s mother and brother were tested, resulting in the same exact translocation. In this study, we describe all possible meiotic segregations regarding this translocation, as well as the clinical phenotypes which could arise, if unbalanced products of conception survive. This is a rare case of familial complex chromosome rearrangement, giving a view for its reproductive consequences.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-017-0893-7</identifier><identifier>PMID: 28236108</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Banding ; Breakpoints ; Chromosome Aberrations ; Chromosome Banding ; Chromosome rearrangements ; Chromosome translocations ; Chromosomes ; Chromosomes, Human, Pair 1 - genetics ; Chromosomes, Human, Pair 11 - genetics ; Chromosomes, Human, Pair 8 - genetics ; Cytogenetic Analysis - methods ; Female ; Genetic counseling ; Genetic screening ; Genetics ; Gynecology ; Human Genetics ; Humans ; In Situ Hybridization, Fluorescence - methods ; Karyotyping ; Male ; Medicine ; Medicine &amp; Public Health ; Meiosis ; Pedigree ; Reproduction - genetics ; Reproductive failure ; Reproductive Medicine ; Segregations ; Translocation ; Translocation, Genetic - genetics</subject><ispartof>Journal of assisted reproduction and genetics, 2017-05, Vol.34 (5), p.659-669</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>Journal of Assisted Reproduction and Genetics is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-b5d20bbcbf866d75b8bd80d5dcc2bf319d37fd8672537936e7d3229a6b6e49673</citedby><cites>FETCH-LOGICAL-c470t-b5d20bbcbf866d75b8bd80d5dcc2bf319d37fd8672537936e7d3229a6b6e49673</cites><orcidid>0000-0002-6688-801X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427656/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427656/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27925,27926,41489,42558,51320,53792,53794</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28236108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trpchevska, Natalia</creatorcontrib><creatorcontrib>Dimova, Ivanka</creatorcontrib><creatorcontrib>Arabadji, Tatyana</creatorcontrib><creatorcontrib>Milachich, Tanya</creatorcontrib><creatorcontrib>Angelova, Svetlana</creatorcontrib><creatorcontrib>Dimitrova, Magdalena</creatorcontrib><creatorcontrib>Hristova-Savova, Mariela</creatorcontrib><creatorcontrib>Andreeva, Petya</creatorcontrib><creatorcontrib>Timeva, Tania</creatorcontrib><creatorcontrib>Shterev, Atanas</creatorcontrib><title>A family study of complex chromosome rearrangement involving chromosomes 1, 8, and 11 and its reproductive consequences</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Complex chromosome translocations are structural chromosomal rearrangements involving three or more chromosomes and more than two breakpoints. A complex chromosome rearrangement was detected in a phenotypically normal female patient that was referred to the hospital for genetic counseling due to reproductive failure. A cytogenetic evaluation was performed, according to standard method of chromosomal analysis, using G-banding technique. The patient’s karyotype showed a balanced complex chromosome rearrangement (BCCR) involving chromosomes 1, 8, and 11 with three breakpoints 1p31, 8q13, and 11q23. The karyotype designed according to ISCN (2013), is 46,XX,t(1;8;11)(p31;q13;q23) (8qter→8q13::1p31→1qter;8pter→8q13::11q23→11qter;11pter→11q23::1p31→1pter). Additionally, the proband’s mother and brother were tested, resulting in the same exact translocation. In this study, we describe all possible meiotic segregations regarding this translocation, as well as the clinical phenotypes which could arise, if unbalanced products of conception survive. This is a rare case of familial complex chromosome rearrangement, giving a view for its reproductive consequences.</description><subject>Banding</subject><subject>Breakpoints</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Banding</subject><subject>Chromosome rearrangements</subject><subject>Chromosome translocations</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 1 - genetics</subject><subject>Chromosomes, Human, Pair 11 - genetics</subject><subject>Chromosomes, Human, Pair 8 - genetics</subject><subject>Cytogenetic Analysis - methods</subject><subject>Female</subject><subject>Genetic counseling</subject><subject>Genetic screening</subject><subject>Genetics</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence - methods</subject><subject>Karyotyping</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Meiosis</subject><subject>Pedigree</subject><subject>Reproduction - genetics</subject><subject>Reproductive failure</subject><subject>Reproductive Medicine</subject><subject>Segregations</subject><subject>Translocation</subject><subject>Translocation, Genetic - genetics</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1UclKBDEUDKK4f4AXCXi1Nctk6Ysg4gaCFz2HbD22dCdj0j06f2_GURkPnurBq6pXvALgCKMzjJA4zxhJzCqERYVkTSuxAXYxE2WgFG2WGTFZoQmXO2Av51eEUC0J3QY7pAAv4l3wfgkb3bfdAuZhdAsYG2hjP-v8B7QvKfYxx97D5HVKOkx978MA2zCP3bwN0zVKhvgUylOog4MYf0E75CKcpehGO7RzX4xD9m-jD9bnA7DV6C77w2_cB883109Xd9XD4-391eVDZScCDZVhjiBjrGkk504wI42TyDFnLTENxbWjonGSC8KoqCn3wlFCas0N95OaC7oPLla-s9H03tmSP-lOzVLb67RQUbfq7ya0L2oa54pNiOCMF4OTb4MUS_Y8qNc4plAyKyzrWpQG5JKFVyybYs7JN78XMFLLrtSqK1W6Usuu1DLa8Xq0X8VPOYVAVoRcVuX5ae30v66fbbGhuA</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Trpchevska, Natalia</creator><creator>Dimova, Ivanka</creator><creator>Arabadji, Tatyana</creator><creator>Milachich, Tanya</creator><creator>Angelova, Svetlana</creator><creator>Dimitrova, Magdalena</creator><creator>Hristova-Savova, Mariela</creator><creator>Andreeva, Petya</creator><creator>Timeva, Tania</creator><creator>Shterev, Atanas</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6688-801X</orcidid></search><sort><creationdate>20170501</creationdate><title>A family study of complex chromosome rearrangement involving chromosomes 1, 8, and 11 and its reproductive consequences</title><author>Trpchevska, Natalia ; Dimova, Ivanka ; Arabadji, Tatyana ; Milachich, Tanya ; Angelova, Svetlana ; Dimitrova, Magdalena ; Hristova-Savova, Mariela ; Andreeva, Petya ; Timeva, Tania ; Shterev, Atanas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-b5d20bbcbf866d75b8bd80d5dcc2bf319d37fd8672537936e7d3229a6b6e49673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Banding</topic><topic>Breakpoints</topic><topic>Chromosome Aberrations</topic><topic>Chromosome Banding</topic><topic>Chromosome rearrangements</topic><topic>Chromosome translocations</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Pair 1 - genetics</topic><topic>Chromosomes, Human, Pair 11 - genetics</topic><topic>Chromosomes, Human, Pair 8 - genetics</topic><topic>Cytogenetic Analysis - methods</topic><topic>Female</topic><topic>Genetic counseling</topic><topic>Genetic screening</topic><topic>Genetics</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence - methods</topic><topic>Karyotyping</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Meiosis</topic><topic>Pedigree</topic><topic>Reproduction - genetics</topic><topic>Reproductive failure</topic><topic>Reproductive Medicine</topic><topic>Segregations</topic><topic>Translocation</topic><topic>Translocation, Genetic - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trpchevska, Natalia</creatorcontrib><creatorcontrib>Dimova, Ivanka</creatorcontrib><creatorcontrib>Arabadji, Tatyana</creatorcontrib><creatorcontrib>Milachich, Tanya</creatorcontrib><creatorcontrib>Angelova, Svetlana</creatorcontrib><creatorcontrib>Dimitrova, Magdalena</creatorcontrib><creatorcontrib>Hristova-Savova, Mariela</creatorcontrib><creatorcontrib>Andreeva, Petya</creatorcontrib><creatorcontrib>Timeva, Tania</creatorcontrib><creatorcontrib>Shterev, Atanas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trpchevska, Natalia</au><au>Dimova, Ivanka</au><au>Arabadji, Tatyana</au><au>Milachich, Tanya</au><au>Angelova, Svetlana</au><au>Dimitrova, Magdalena</au><au>Hristova-Savova, Mariela</au><au>Andreeva, Petya</au><au>Timeva, Tania</au><au>Shterev, Atanas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A family study of complex chromosome rearrangement involving chromosomes 1, 8, and 11 and its reproductive consequences</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>34</volume><issue>5</issue><spage>659</spage><epage>669</epage><pages>659-669</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Complex chromosome translocations are structural chromosomal rearrangements involving three or more chromosomes and more than two breakpoints. A complex chromosome rearrangement was detected in a phenotypically normal female patient that was referred to the hospital for genetic counseling due to reproductive failure. A cytogenetic evaluation was performed, according to standard method of chromosomal analysis, using G-banding technique. The patient’s karyotype showed a balanced complex chromosome rearrangement (BCCR) involving chromosomes 1, 8, and 11 with three breakpoints 1p31, 8q13, and 11q23. The karyotype designed according to ISCN (2013), is 46,XX,t(1;8;11)(p31;q13;q23) (8qter→8q13::1p31→1qter;8pter→8q13::11q23→11qter;11pter→11q23::1p31→1pter). Additionally, the proband’s mother and brother were tested, resulting in the same exact translocation. In this study, we describe all possible meiotic segregations regarding this translocation, as well as the clinical phenotypes which could arise, if unbalanced products of conception survive. This is a rare case of familial complex chromosome rearrangement, giving a view for its reproductive consequences.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28236108</pmid><doi>10.1007/s10815-017-0893-7</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6688-801X</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1058-0468
ispartof Journal of assisted reproduction and genetics, 2017-05, Vol.34 (5), p.659-669
issn 1058-0468
1573-7330
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5427656
source MEDLINE; SpringerNature Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Banding
Breakpoints
Chromosome Aberrations
Chromosome Banding
Chromosome rearrangements
Chromosome translocations
Chromosomes
Chromosomes, Human, Pair 1 - genetics
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 8 - genetics
Cytogenetic Analysis - methods
Female
Genetic counseling
Genetic screening
Genetics
Gynecology
Human Genetics
Humans
In Situ Hybridization, Fluorescence - methods
Karyotyping
Male
Medicine
Medicine & Public Health
Meiosis
Pedigree
Reproduction - genetics
Reproductive failure
Reproductive Medicine
Segregations
Translocation
Translocation, Genetic - genetics
title A family study of complex chromosome rearrangement involving chromosomes 1, 8, and 11 and its reproductive consequences
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T14%3A03%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20family%20study%20of%20complex%20chromosome%20rearrangement%20involving%20chromosomes%201,%208,%20and%2011%20and%20its%20reproductive%20consequences&rft.jtitle=Journal%20of%20assisted%20reproduction%20and%20genetics&rft.au=Trpchevska,%20Natalia&rft.date=2017-05-01&rft.volume=34&rft.issue=5&rft.spage=659&rft.epage=669&rft.pages=659-669&rft.issn=1058-0468&rft.eissn=1573-7330&rft_id=info:doi/10.1007/s10815-017-0893-7&rft_dat=%3Cproquest_pubme%3E1899708186%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1899708186&rft_id=info:pmid/28236108&rfr_iscdi=true