In Vitro Evaluations and In Vivo Toxicity and Efficacy Studies of MFM501 against MRSA

Previously we have discovered a synthetically derived pyrrolidone alkaloid, MFM501, exhibiting good inhibitory activity against 53 MRSA and MSSA isolates with low cytotoxicity against three normal cell-lines with IC50 values at >625 µg/ml. Time-kill assay, scanning electron microscopy (SEM) analy...

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Veröffentlicht in:	BioMed research international 2017-01, Vol.2017 (2017), p.1-10
Hauptverfasser:	Mohamad Ridhwan, Mohamad Jemain, Sahdan, Rohana, Mohammat, Mohd Fazli, Syed Mohammad, Sharifah Aminah, Mohtar, Mastura, Johari, Saiful Azmi, Mohamed, Azman
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - toxicity Antibiotics Antimicrobial agents Biological activity Cytotoxicity Health aspects Humans Laboratories Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - ultrastructure Mice Microbial Sensitivity Tests Microscopy, Electron, Scanning Natural products Pyrrolidinones - administration & dosage Pyrrolidinones - pharmacology Pyrrolidinones - toxicity Scanning electron microscopy Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus infections Studies
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