A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N 6 -methyladenosine demethylase FTO

The AlkB family of nucleic acid demethylases are of intense biological and medical interest because of their roles in nucleic acid repair and epigenetic modification. However their functional and molecular mechanisms are unclear, hence, there is strong interest in developing selective inhibitors for...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical science (Cambridge) 2015-01, Vol.6 (1), p.112-122
Hauptverfasser:	Toh, Joel D W, Sun, Lingyi, Lau, Lisa Z M, Tan, Jackie, Low, Joanne J A, Tang, Colin W Q, Cheong, Eleanor J Y, Tan, Melissa J H, Chen, Yun, Hong, Wanjin, Gao, Yong-Gui, Woon, Esther C Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!