CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels

Inhibition of the mitochondrial Na + /Ca 2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca 2+ homeostasis. However, the Ca 2+ signaling pathways and stores underlying neuroprotection by that inhibitor are not well defined. In the p...

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Veröffentlicht in:	Cell death & disease 2014-04, Vol.5 (4), p.e1156-e1156
Hauptverfasser:	Ruiz, A, Alberdi, E, Matute, C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1697 631/378/1934 631/80/86/1999 Animals Antibodies Biochemistry Biomedical and Life Sciences Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium Channels - metabolism Calpain - metabolism Cell Biology Cell Culture Cells, Cultured Clonazepam - analogs & derivatives Clonazepam - pharmacology Cytoprotection - drug effects Cytosol - drug effects Cytosol - metabolism Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Immunology Intracellular Space - drug effects Intracellular Space - metabolism Life Sciences Mitochondria - drug effects Mitochondria - metabolism N-Methylaspartate - pharmacology Neurons - cytology Neurons - drug effects Neuroprotective Agents - pharmacology Neurotoxins - toxicity Original original-article Rats, Sprague-Dawley Sodium-Calcium Exchanger - antagonists & inhibitors Sodium-Calcium Exchanger - metabolism Thiazepines - pharmacology
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