Prolonged Temozolomide Maintenance Therapy in Newly Diagnosed Glioblastoma

Background The impact of prolonging temozolomide (TMZ) maintenance beyond six cycles in newly diagnosed glioblastoma (GBM) remains a topic of discussion. We investigated the effects of prolonged TMZ maintenance on progression‐free survival (PFS) and overall survival (OS). Patients and Methods In thi...

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Veröffentlicht in:	The oncologist (Dayton, Ohio) Ohio), 2017-05, Vol.22 (5), p.570-575
Hauptverfasser:	Skardelly, Marco, Dangel, Elena, Gohde, Julia, Noell, Susan, Behling, Felix, Lepski, Guilherme, Borchers, Christian, Koch, Marilin, Schittenhelm, Jens, Bisdas, Sotirios, Naumann, Aline, Paulsen, Frank, Zips, Daniel, von Hehn, Ulrike, Ritz, Rainer, Tatagiba, Marcos Soares, Tabatabai, Ghazaleh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents, Alkylating - administration & dosage Antineoplastic Agents, Alkylating - adverse effects Chemotherapy, Adjuvant - adverse effects Combined Modality Therapy Dacarbazine - administration & dosage Dacarbazine - adverse effects Dacarbazine - analogs & derivatives Disease-Free Survival Female Glioblastoma Glioblastoma - drug therapy Glioblastoma - pathology Glioblastoma - radiotherapy Humans Kaplan-Meier Estimate Maintenance chemotherapy Male Middle Aged Neuro‐Oncology Proportional Hazards Models Risk Factors Temozolomide
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