Regulation of transcriptional activators by DNA-binding domain ubiquitination

Ubiquitin is a key component of the regulatory network that maintains gene expression in eukaryotes, yet the molecular mechanism(s) by which non-degradative ubiquitination modulates transcriptional activator (TA) function is unknown. Here endogenous p53, a stress-activated transcription factor requi...

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Veröffentlicht in:	Cell death and differentiation 2017-05, Vol.24 (5), p.903-916
Hauptverfasser:	Landré, Vivien, Revi, Bhindu, Mir, Maria Gil, Verma, Chandra, Hupp, Ted R, Gilbert, Nick, Ball, Kathryn L
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 14 14/63 631/535/1267 82/83 96 96/106 Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell death Cell Line, Tumor Chromatin - chemistry Chromatin - metabolism Crystallography, X-Ray DNA - chemistry DNA - genetics DNA - metabolism Gene expression Homeostasis Humans Imidazoles - pharmacology Interferon Regulatory Factor-1 - chemistry Interferon Regulatory Factor-1 - genetics Interferon Regulatory Factor-1 - metabolism Life Sciences Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism Melanocytes - cytology Melanocytes - drug effects Melanocytes - metabolism Models, Molecular Molecular weight Original Paper Piperazines - pharmacology Protein Binding Protein Domains Proteins Proto-Oncogene Proteins c-mdm2 - chemistry Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Stem Cells Thermodynamics Trans-Activators - chemistry Trans-Activators - genetics Trans-Activators - metabolism Transcription factors Transcriptional Activation Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Ubiquitin - chemistry Ubiquitin - genetics Ubiquitin - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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