An Immune Atlas of Clear Cell Renal Cell Carcinoma

Immune cells in the tumor microenvironment modulate cancer progression and are attractive therapeutic targets. Macrophages and T cells are key components of the microenvironment, yet their phenotypes and relationships in this ecosystem and to clinical outcomes are ill defined. We used mass cytometry...

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Veröffentlicht in:	Cell 2017-05, Vol.169 (4), p.736-749.e18
Hauptverfasser:	Chevrier, Stéphane, Levine, Jacob Harrison, Zanotelli, Vito Riccardo Tomaso, Silina, Karina, Schulz, Daniel, Bacac, Marina, Ries, Carola Hermine, Ailles, Laurie, Jewett, Michael Alexander Spencer, Moch, Holger, van den Broek, Maries, Beisel, Christian, Stadler, Michael Beda, Gedye, Craig, Reis, Bernhard, Pe’er, Dana, Bodenmiller, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	antibodies biomarkers Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - pathology clear cell renal cell carcinoma disease course ecosystems Humans Image Cytometry immune cell atlas Immune Tolerance immunosuppression immunotherapy Kidney - cytology Kidney Neoplasms - immunology Kidney Neoplasms - pathology macrophage macrophages Macrophages - immunology Macrophages - pathology mass cytometry patients phenotype renal cell carcinoma Resource Single-Cell Analysis T cell T-lymphocytes T-Lymphocytes - immunology T-Lymphocytes - pathology Tumor Microenvironment
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