The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension

The spatial organization of chromosomes influences many nuclear processes including gene expression. The cohesin complex shapes the 3D genome by looping together CTCF sites along chromosomes. We show here that chromatin loop size can be increased and that the duration with which cohesin embraces DNA...

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Veröffentlicht in:	Cell 2017-05, Vol.169 (4), p.693-707.e14
Hauptverfasser:	Haarhuis, Judith H.I., van der Weide, Robin H., Blomen, Vincent A., Yáñez-Cuna, J. Omar, Amendola, Mario, van Ruiten, Marjon S., Krijger, Peter H.L., Teunissen, Hans, Medema, René H., van Steensel, Bas, Brummelkamp, Thijn R., de Wit, Elzo, Rowland, Benjamin D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - metabolism Biotechnology Carrier Proteins - metabolism CCCTC-Binding Factor Cell Cycle Proteins - metabolism Cell Nucleus - metabolism Cellular Biology Chromatin - metabolism chromatin looping Chromosomal Proteins, Non-Histone - metabolism cohesin Cohesins CTCF DNA-Binding Proteins Fatty Acid Elongases Gene Editing Hematology Human health and pathology Humans Life Sciences loop extrusion MAU2 Multiprotein Complexes - metabolism NIPBL Nuclear Proteins - metabolism Proto-Oncogene Proteins - metabolism Repressor Proteins - metabolism SCC2 SCC4 TADs WAPL
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