USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt

USP22, a member of the deubiquitinases (DUBs) family, is known to be a key subunit of the human Spt-Ada-Gcn5 acetyltransferase (hSAGA) transcriptional cofactor complex. Within hSAGA, USP22 removes ubiquitin from histone proteins, thus regulating the transcription and expression of downstream genes....

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Veröffentlicht in:	Oncotarget 2017-04, Vol.8 (15), p.24728-24740
Hauptverfasser:	Zhang, Jing, Luo, Nan, Tian, Yu, Li, Jiazhi, Yang, Xiaozhou, Yin, Huimin, Xiao, Congshu, Sheng, Jie, Li, Yang, Tang, Bo, Li, Rongkuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Proliferation - drug effects Drug Resistance, Neoplasm Female Fluorouracil - pharmacology Fluorouracil - therapeutic use Gene Knockdown Techniques Hep G2 Cells Humans Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Mice Mice, Nude Middle Aged Prognosis Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Research Paper Smad4 Protein - genetics Smad4 Protein - metabolism Thiolester Hydrolases - biosynthesis Thiolester Hydrolases - deficiency Thiolester Hydrolases - metabolism Up-Regulation - drug effects Xenograft Model Antitumor Assays
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