ERCC1-expressing circulating tumor cells as a potential diagnostic tool for monitoring response to platinum-based chemotherapy and for predicting post-therapeutic outcome of ovarian cancer

We recently showed that the presence of ERCC1+CTCs is an independent predictive biomarker for platinum-resistance and poor prognosis of ovarian cancer. The goal of our current research was to determine how the auxiliary assessment of ERCC1-transcripts influences overall CTC-detection rate. We extend...

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Veröffentlicht in:	Oncotarget 2017-04, Vol.8 (15), p.24303-24313
Hauptverfasser:	Chebouti, Issam, Kuhlmann, Jan Dominik, Buderath, Paul, Weber, Stephan, Wimberger, Pauline, Bokeloh, Yvonne, Hauch, Siegfried, Kimmig, Rainer, Kasimir-Bauer, Sabine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - blood DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - blood DNA-Binding Proteins - genetics Endonucleases - biosynthesis Endonucleases - blood Endonucleases - genetics Female Humans Middle Aged Neoplastic Cells, Circulating - metabolism Neoplastic Cells, Circulating - pathology Organoplatinum Compounds - administration & dosage Ovarian Neoplasms - blood Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Predictive Value of Tests Prognosis Research Paper Treatment Outcome
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