Early pathogenesis during infectious bursal disease in susceptible chickens is associated with changes in B cell genomic methylation and loss of genome integrity

We propose a model by which an increase in the genomic modification, 5-hydroxymethylcytosine (5hmC), contributes to B cell death within the chicken bursa of Fabricus (BF) infected with infectious bursal disease virus (IBDV). Our findings indicate that, following an IBDV infection, Rhode Island Red (...

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Veröffentlicht in:	Developmental and comparative immunology 2017-08, Vol.73, p.169-174
Hauptverfasser:	Ciccone, Nick A., Smith, Lorraine P., Mwangi, William, Boyd, Amy, Broadbent, Andrew J., Smith, Adrian L., Nair, Venugopal
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxymethylcytosine (5hmC) 5-Methylcytosine - analogs & derivatives 5-Methylcytosine - analysis Animals B-cell B-lymphocytes B-Lymphocytes - immunology Birds Birnaviridae Infections - veterinary Capsid protein CD40L CD40L protein Cell death Chickens Chickens - immunology Chickens - virology coat proteins death DNA methylation DNA Methylation - immunology Egress FasL protein Gene expression genome Genomes Genomic instability Immune response immunopathology Immunosuppression inducible nitric oxide synthase Infections Infectious bursal disease Infectious bursal disease virus Infectious bursal disease virus (IBDV) Infectious bursal disease virus - immunology Infectious bursal disease virus - pathogenicity Infectious diseases Infiltration Lymphocytes Lymphocytes B Lymphocytes T methylation Nitric-oxide synthase Pathogenesis Poultry Poultry Diseases - immunology Rhode Island Red Stability T-cell T-lymphocytes Viruses
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