Room temperature housing results in premature cancellous bone loss in growing female mice: implications for the mouse as a preclinical model for age-related bone loss

Summary Room temperature housing (22 °C) results in premature cancellous bone loss in female mice. The bone loss was prevented by housing mice at thermoneutral temperature (32 °C). Thermogenesis differs markedly between mice and humans and mild cold stress induced by standard room temperature housin...

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Veröffentlicht in:	Osteoporosis international 2016-10, Vol.27 (10), p.3091-3101
Hauptverfasser:	Iwaniec, U. T., Philbrick, K. A., Wong, C. P., Gordon, J. L., Kahler-Quesada, A. M., Olson, D. A., Branscum, A. J., Sargent, J. L., DeMambro, V. E., Rosen, C. J., Turner, R. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose tissue (brown) Age Animal models Animals Body Temperature Regulation Bone growth Bone loss Bone marrow Bone mass Bone resorption Bone turnover Cancellous bone Cancellous Bone - physiology Cortical bone Disease Models, Animal Endocrinology Epiphysis Female Femur Gene expression Heat loss Homeotherms Housing Housing, Animal Medicine Medicine & Public Health Metaphysis Mice Mice, Inbred C3H Mice, Inbred C57BL Original Article Orthopedics Osteogenesis Osteoporosis Osteoporosis - physiopathology Rheumatology Rodents Temperature Temperature effects Thermogenesis Thermoregulation Uncoupling protein 1
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