NGP 555, a γ-secretase modulator, lowers the amyloid biomarker, Aβ42, in cerebrospinal fluid while preventing Alzheimer's disease cognitive decline in rodents

Abstract Introduction Alzheimer's disease (AD) is defined by the progressive accumulation of amyloid plaques and neurofibrillary tangles in the brain which precedes cognitive decline by years. Methods Using amyloid biomarkers, chemical modeling, mouse behavioral models, and drug development tec...

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Veröffentlicht in:	Alzheimer's & dementia : translational research & clinical interventions 2017-01, Vol.3 (1), p.65-73
Hauptverfasser:	Kounnas, Maria Z, Lane-Donovan, Courtney, Nowakowski, Dan W, Herz, Joachim, Comer, William T
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's Amyloid Biomarkers Cerebrospinal fluid Cognition Dementia Gamma-secretase Modulator Neurology Other Pathology Prevention
Online-Zugang:	Volltext
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