Hyaluronan synthase assembles hyaluronan on a [GlcNAc(β1,4)]n-GlcNAc(α1→)UDP primer and hyaluronan retains this residual chitin oligomer as a cap at the nonreducing end

Class I hyaluronan synthases (HAS) assemble [GlcNAc(β1,4)GlcUA(β1,3)]n-UDP at the reducing end and also make chitin. Streptococcus equisimilis HAS (SeHAS) also synthesizes chitin-UDP oligosaccharides, (GlcNAc-β1,4)n-GlcNAc(α1→)UDP (Weigel et al. 2015). Here we determined if HAS uses chitin-UDPs as p...

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Veröffentlicht in:	Glycobiology (Oxford) 2017-06, Vol.27 (6), p.536-554
Hauptverfasser:	Weigel, Paul H, Baggenstoss, Bruce A, Washburn, Jennifer L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - chemistry Bacterial Proteins - chemistry Bacterial Proteins - metabolism Chitin - chemistry Hexosaminidases - chemistry Hexosaminidases - metabolism Hyaluronan Synthases - chemistry Hyaluronan Synthases - metabolism Hyaluronic Acid - chemistry Original articles Plant Proteins - chemistry Plant Proteins - metabolism Streptococcus - enzymology Uridine Diphosphate - chemistry
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