Impaired Corneal Sensation and Nerve Loss in a Type 2 Rat Model of Chronic Diabetes Is Reversible With Combination Therapy of Menhaden Oil, α-Lipoic Acid, and Enalapril

PURPOSE:This study investigated the efficacy of monotherapy versus combination of menhaden oil, α-lipoic acid, and enalapril on corneal sensation and morphometry and other neuropathy-related endpoints in a rat model of type 2 diabetes. METHODS:Male Sprague-Dawley rats (aged 12 weeks) were fed a high...

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Veröffentlicht in:	Cornea 2017-06, Vol.36 (6), p.725-731
Hauptverfasser:	Davidson, Eric P, Coppey, Lawrence J, Shevalye, Hanna, Obrosov, Alexander, Kardon, Randy H, Yorek, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin - metabolism Angiotensin-Converting Enzyme Inhibitors - administration & dosage Animals Blood Glucose - metabolism Cornea - innervation Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Diabetic Neuropathies - physiopathology Diet, High-Fat Drug Therapy, Combination Enalapril - administration & dosage Fish Oils - administration & dosage Hypesthesia - physiopathology Lipids - blood Male Peptidyl-Dipeptidase A - metabolism Rats Rats, Sprague-Dawley Streptozocin Thiobarbituric Acid Reactive Substances - metabolism Thioctic Acid - administration & dosage Trigeminal Nerve Diseases - physiopathology
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