Endothelin causes transactivation of the EGFR and HER2 in non-small cell lung cancer cells

•ET-1 addition to NSCLC cells causes tyrosine phosphorylation of the EGFR, HER2 and ERK.•ET-1 binds with high affinity to NSCLC and causes elevated cytosolic Ca2+ which is blocked by the ETAR antagonists BQ123 and ZD4054.•The ability of ET-1 to cause EGFR and HER2 transactivation is blocked by ETAR...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2017-04, Vol.90, p.90-99
Hauptverfasser:	Moody, Terry W., Ramos-Alvarez, Irene, Moreno, Paula, Mantey, Samuel A., Ridnour, Lisa, Wink, David, Jensen, Robert T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell Proliferation - drug effects EGFR Endothelin Endothelins - genetics Endothelins - metabolism Gene Expression Regulation, Neoplastic - drug effects HER2 Humans Lung cancer Peptides, Cyclic - administration & dosage Protein Kinase Inhibitors - administration & dosage Pyrrolidines - administration & dosage Quinazolines - administration & dosage Receptor, Endothelin A - genetics Receptor, Endothelin B - genetics Receptor, Epidermal Growth Factor - genetics Receptor, ErbB-2 - genetics Transactivation Transcriptional Activation - drug effects
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