Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis
Brown adipose tissue (BAT) is a specialized fat tissue that has a high capacity to dissociate cellular respiration from ATP utilization, resulting in the release of stored energy as heat. Adult humans possess a substantial amount of BAT in the form of constitutively active brown fat or inducible bei...
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| Veröffentlicht in: | Advances in nutrition (Bethesda, Md.) Md.), 2017-05, Vol.8 (3), p.473-483 |
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| creator | Okla, Meshail Kim, Jiyoung Koehler, Karsten Chung, Soonkyu |
| description | Brown adipose tissue (BAT) is a specialized fat tissue that has a high capacity to dissociate cellular respiration from ATP utilization, resulting in the release of stored energy as heat. Adult humans possess a substantial amount of BAT in the form of constitutively active brown fat or inducible beige fat. BAT activity in humans is inversely correlated with adiposity, blood glucose concentrations, and insulin sensitivity; this suggests that strategies aimed at BAT-mediated bioenergetics are an attractive therapeutic target in combating the continuing epidemic of obesity and diabetes. Despite advances in knowledge regarding the developmental lineage and transcriptional regulators of brown and beige adipocytes, our current understanding of environmental modifiers of BAT thermogenesis, such as diet, is limited. In this review, we consolidated the latest research on dietary molecules that may serve to promote BAT thermogenesis. Here, we summarized the thermogenic function of selected phytochemicals (e.g., capsaicin, resveratrol, curcumin, green tea, and berberine), dietary fatty acids (e.g., fish oil and conjugated linoleic acids), and all-trans retinoic acid, a vitamin A metabolite. We also delineated the proposed mechanisms whereby these dietary molecules promote BAT activity and/or browning of white adipose tissue. Characterizing thermogenic dietary factors may offer novel insight into revising nutritional intervention strategies aimed at obesity and diabetes prevention and management. |
| doi_str_mv | 10.3945/an.116.014332 |
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Adult humans possess a substantial amount of BAT in the form of constitutively active brown fat or inducible beige fat. BAT activity in humans is inversely correlated with adiposity, blood glucose concentrations, and insulin sensitivity; this suggests that strategies aimed at BAT-mediated bioenergetics are an attractive therapeutic target in combating the continuing epidemic of obesity and diabetes. Despite advances in knowledge regarding the developmental lineage and transcriptional regulators of brown and beige adipocytes, our current understanding of environmental modifiers of BAT thermogenesis, such as diet, is limited. In this review, we consolidated the latest research on dietary molecules that may serve to promote BAT thermogenesis. Here, we summarized the thermogenic function of selected phytochemicals (e.g., capsaicin, resveratrol, curcumin, green tea, and berberine), dietary fatty acids (e.g., fish oil and conjugated linoleic acids), and all-trans retinoic acid, a vitamin A metabolite. We also delineated the proposed mechanisms whereby these dietary molecules promote BAT activity and/or browning of white adipose tissue. Characterizing thermogenic dietary factors may offer novel insight into revising nutritional intervention strategies aimed at obesity and diabetes prevention and management.</description><identifier>ISSN: 2161-8313</identifier><identifier>ISSN: 2156-5376</identifier><identifier>EISSN: 2156-5376</identifier><identifier>DOI: 10.3945/an.116.014332</identifier><identifier>PMID: 28507012</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>adenosine triphosphate ; adipocytes ; Adipose Tissue, Beige - drug effects ; Adipose Tissue, Beige - metabolism ; Adipose Tissue, Brown - drug effects ; Adipose Tissue, Brown - metabolism ; Adipose Tissue, White - drug effects ; Adipose Tissue, White - metabolism ; adiposity ; beige adipocytes ; berberine ; blood glucose ; brown adipocyte ; brown adipose tissue ; capsaicin ; cell respiration ; chemical constituents of plants ; curcumin ; diabetes ; Diabetes Mellitus - diet therapy ; Diabetes Mellitus - drug therapy ; Diabetes Mellitus - metabolism ; Diet ; dietary fat ; Dietary Fats - pharmacology ; dietary molecule ; Dietary Supplements ; energy ; energy metabolism ; Energy Metabolism - drug effects ; fish oils ; green tea ; heat production ; Humans ; insulin resistance ; linoleic acid ; metabolites ; nutritional intervention ; obesity ; Obesity - diet therapy ; Obesity - drug therapy ; Obesity - metabolism ; Plant Extracts - pharmacology ; resveratrol ; retinoic acid ; Reviews ; thermogenesis ; Thermogenesis - drug effects ; transcription factors ; UCP1 ; vitamin A ; Vitamin A - pharmacology ; Vitamins - pharmacology ; WAT browning ; white adipose tissue</subject><ispartof>Advances in nutrition (Bethesda, Md.), 2017-05, Vol.8 (3), p.473-483</ispartof><rights>2017 © 2017 American Society for Nutrition</rights><rights>2017 American Society for Nutrition.</rights><rights>2017 American Society for Nutrition 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-930357143569985cec6b436c9744c5fdd8a79cf418db5c2fa5e5f9cb3b0b46823</citedby><cites>FETCH-LOGICAL-c534t-930357143569985cec6b436c9744c5fdd8a79cf418db5c2fa5e5f9cb3b0b46823</cites><orcidid>0000-0002-9618-2069 ; 0000-0001-6279-7017</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421122/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421122/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28507012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okla, Meshail</creatorcontrib><creatorcontrib>Kim, Jiyoung</creatorcontrib><creatorcontrib>Koehler, Karsten</creatorcontrib><creatorcontrib>Chung, Soonkyu</creatorcontrib><title>Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis</title><title>Advances in nutrition (Bethesda, Md.)</title><addtitle>Adv Nutr</addtitle><description>Brown adipose tissue (BAT) is a specialized fat tissue that has a high capacity to dissociate cellular respiration from ATP utilization, resulting in the release of stored energy as heat. Adult humans possess a substantial amount of BAT in the form of constitutively active brown fat or inducible beige fat. BAT activity in humans is inversely correlated with adiposity, blood glucose concentrations, and insulin sensitivity; this suggests that strategies aimed at BAT-mediated bioenergetics are an attractive therapeutic target in combating the continuing epidemic of obesity and diabetes. Despite advances in knowledge regarding the developmental lineage and transcriptional regulators of brown and beige adipocytes, our current understanding of environmental modifiers of BAT thermogenesis, such as diet, is limited. In this review, we consolidated the latest research on dietary molecules that may serve to promote BAT thermogenesis. Here, we summarized the thermogenic function of selected phytochemicals (e.g., capsaicin, resveratrol, curcumin, green tea, and berberine), dietary fatty acids (e.g., fish oil and conjugated linoleic acids), and all-trans retinoic acid, a vitamin A metabolite. We also delineated the proposed mechanisms whereby these dietary molecules promote BAT activity and/or browning of white adipose tissue. Characterizing thermogenic dietary factors may offer novel insight into revising nutritional intervention strategies aimed at obesity and diabetes prevention and management.</description><subject>adenosine triphosphate</subject><subject>adipocytes</subject><subject>Adipose Tissue, Beige - drug effects</subject><subject>Adipose Tissue, Beige - metabolism</subject><subject>Adipose Tissue, Brown - drug effects</subject><subject>Adipose Tissue, Brown - metabolism</subject><subject>Adipose Tissue, White - drug effects</subject><subject>Adipose Tissue, White - metabolism</subject><subject>adiposity</subject><subject>beige adipocytes</subject><subject>berberine</subject><subject>blood glucose</subject><subject>brown adipocyte</subject><subject>brown adipose tissue</subject><subject>capsaicin</subject><subject>cell respiration</subject><subject>chemical constituents of plants</subject><subject>curcumin</subject><subject>diabetes</subject><subject>Diabetes Mellitus - diet therapy</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diet</subject><subject>dietary fat</subject><subject>Dietary Fats - pharmacology</subject><subject>dietary molecule</subject><subject>Dietary Supplements</subject><subject>energy</subject><subject>energy metabolism</subject><subject>Energy Metabolism - drug effects</subject><subject>fish oils</subject><subject>green tea</subject><subject>heat production</subject><subject>Humans</subject><subject>insulin resistance</subject><subject>linoleic acid</subject><subject>metabolites</subject><subject>nutritional intervention</subject><subject>obesity</subject><subject>Obesity - diet therapy</subject><subject>Obesity - drug therapy</subject><subject>Obesity - metabolism</subject><subject>Plant Extracts - pharmacology</subject><subject>resveratrol</subject><subject>retinoic acid</subject><subject>Reviews</subject><subject>thermogenesis</subject><subject>Thermogenesis - drug effects</subject><subject>transcription factors</subject><subject>UCP1</subject><subject>vitamin A</subject><subject>Vitamin A - pharmacology</subject><subject>Vitamins - pharmacology</subject><subject>WAT browning</subject><subject>white adipose tissue</subject><issn>2161-8313</issn><issn>2156-5376</issn><issn>2156-5376</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kTtPwzAUhS0EAlQ6sqKMLCnxM8mCRMtTVIKhzJbj3LRGiV3stIh_j0sLggEvtnQ_HZ97DkKnOBvRkvELZUcYi1GGGaVkDx0TzEXKaS72N2-B04JieoSGIbxm8XBS5IIeoiNS8CzPMDlGj9cGeuU_klule-dD8uxd53pj58nYu3ebKFsnYzBziESfXMMaWrfswPZfk9kCfOfmYCGYcIIOGtUGGO7uAXq5vZlN7tPp093D5Gqaak5Zn5Y0ozyPlrkoy4Jr0KJiVOgyZ0zzpq4LlZe6YbioK65JozjwptQVrbKKiYLQAbrc6i5XVQe1jma8auXSmy5uIp0y8u_EmoWcu7XkjGBMNgLnOwHv3lYQetmZoKFtlQW3CpLgGBMtGNug6RbV3oXgofn5Bmdy04FUVsYO5LaDyJ_99vZDfycegXwLQExobcDLoA1YDbXxoHtZO_OP9Cfu05Sj</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Okla, Meshail</creator><creator>Kim, Jiyoung</creator><creator>Koehler, Karsten</creator><creator>Chung, Soonkyu</creator><general>Elsevier Inc</general><general>American Society for Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9618-2069</orcidid><orcidid>https://orcid.org/0000-0001-6279-7017</orcidid></search><sort><creationdate>20170501</creationdate><title>Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis</title><author>Okla, Meshail ; Kim, Jiyoung ; Koehler, Karsten ; Chung, Soonkyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-930357143569985cec6b436c9744c5fdd8a79cf418db5c2fa5e5f9cb3b0b46823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>adenosine triphosphate</topic><topic>adipocytes</topic><topic>Adipose Tissue, Beige - drug effects</topic><topic>Adipose Tissue, Beige - metabolism</topic><topic>Adipose Tissue, Brown - drug effects</topic><topic>Adipose Tissue, Brown - metabolism</topic><topic>Adipose Tissue, White - drug effects</topic><topic>Adipose Tissue, White - metabolism</topic><topic>adiposity</topic><topic>beige adipocytes</topic><topic>berberine</topic><topic>blood glucose</topic><topic>brown adipocyte</topic><topic>brown adipose tissue</topic><topic>capsaicin</topic><topic>cell respiration</topic><topic>chemical constituents of plants</topic><topic>curcumin</topic><topic>diabetes</topic><topic>Diabetes Mellitus - diet therapy</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diet</topic><topic>dietary fat</topic><topic>Dietary Fats - pharmacology</topic><topic>dietary molecule</topic><topic>Dietary Supplements</topic><topic>energy</topic><topic>energy metabolism</topic><topic>Energy Metabolism - drug effects</topic><topic>fish oils</topic><topic>green tea</topic><topic>heat production</topic><topic>Humans</topic><topic>insulin resistance</topic><topic>linoleic acid</topic><topic>metabolites</topic><topic>nutritional intervention</topic><topic>obesity</topic><topic>Obesity - diet therapy</topic><topic>Obesity - drug therapy</topic><topic>Obesity - metabolism</topic><topic>Plant Extracts - pharmacology</topic><topic>resveratrol</topic><topic>retinoic acid</topic><topic>Reviews</topic><topic>thermogenesis</topic><topic>Thermogenesis - drug effects</topic><topic>transcription factors</topic><topic>UCP1</topic><topic>vitamin A</topic><topic>Vitamin A - pharmacology</topic><topic>Vitamins - pharmacology</topic><topic>WAT browning</topic><topic>white adipose tissue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okla, Meshail</creatorcontrib><creatorcontrib>Kim, Jiyoung</creatorcontrib><creatorcontrib>Koehler, Karsten</creatorcontrib><creatorcontrib>Chung, Soonkyu</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Advances in nutrition (Bethesda, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okla, Meshail</au><au>Kim, Jiyoung</au><au>Koehler, Karsten</au><au>Chung, Soonkyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis</atitle><jtitle>Advances in nutrition (Bethesda, Md.)</jtitle><addtitle>Adv Nutr</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>8</volume><issue>3</issue><spage>473</spage><epage>483</epage><pages>473-483</pages><issn>2161-8313</issn><issn>2156-5376</issn><eissn>2156-5376</eissn><abstract>Brown adipose tissue (BAT) is a specialized fat tissue that has a high capacity to dissociate cellular respiration from ATP utilization, resulting in the release of stored energy as heat. Adult humans possess a substantial amount of BAT in the form of constitutively active brown fat or inducible beige fat. BAT activity in humans is inversely correlated with adiposity, blood glucose concentrations, and insulin sensitivity; this suggests that strategies aimed at BAT-mediated bioenergetics are an attractive therapeutic target in combating the continuing epidemic of obesity and diabetes. Despite advances in knowledge regarding the developmental lineage and transcriptional regulators of brown and beige adipocytes, our current understanding of environmental modifiers of BAT thermogenesis, such as diet, is limited. In this review, we consolidated the latest research on dietary molecules that may serve to promote BAT thermogenesis. Here, we summarized the thermogenic function of selected phytochemicals (e.g., capsaicin, resveratrol, curcumin, green tea, and berberine), dietary fatty acids (e.g., fish oil and conjugated linoleic acids), and all-trans retinoic acid, a vitamin A metabolite. We also delineated the proposed mechanisms whereby these dietary molecules promote BAT activity and/or browning of white adipose tissue. Characterizing thermogenic dietary factors may offer novel insight into revising nutritional intervention strategies aimed at obesity and diabetes prevention and management.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28507012</pmid><doi>10.3945/an.116.014332</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9618-2069</orcidid><orcidid>https://orcid.org/0000-0001-6279-7017</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | adenosine triphosphate adipocytes Adipose Tissue, Beige - drug effects Adipose Tissue, Beige - metabolism Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Adipose Tissue, White - drug effects Adipose Tissue, White - metabolism adiposity beige adipocytes berberine blood glucose brown adipocyte brown adipose tissue capsaicin cell respiration chemical constituents of plants curcumin diabetes Diabetes Mellitus - diet therapy Diabetes Mellitus - drug therapy Diabetes Mellitus - metabolism Diet dietary fat Dietary Fats - pharmacology dietary molecule Dietary Supplements energy energy metabolism Energy Metabolism - drug effects fish oils green tea heat production Humans insulin resistance linoleic acid metabolites nutritional intervention obesity Obesity - diet therapy Obesity - drug therapy Obesity - metabolism Plant Extracts - pharmacology resveratrol retinoic acid Reviews thermogenesis Thermogenesis - drug effects transcription factors UCP1 vitamin A Vitamin A - pharmacology Vitamins - pharmacology WAT browning white adipose tissue |
| title | Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis |
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