Association of PECAM-1 Gene Polymorphisms with Kawasaki Disease in Chinese Children
Kawasaki disease (KD) is an acute systemic vasculitis complicated by development of coronary artery lesions. PECAM-1 is a kind of cell adhesion molecule, which plays an important role in coronary artery disease. The relationship between PECAM-1 gene polymorphisms and their susceptibility to Kawasaki...
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| Veröffentlicht in: | Disease markers 2017-01, Vol.2017 (2017), p.1-6 |
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| creator | Tian, Lang Chen, Jia Jiang, Jie Han, Dong Li, Zhuoying Yang, Zuocheng |
| description | Kawasaki disease (KD) is an acute systemic vasculitis complicated by development of coronary artery lesions. PECAM-1 is a kind of cell adhesion molecule, which plays an important role in coronary artery disease. The relationship between PECAM-1 gene polymorphisms and their susceptibility to Kawasaki diseases (KD) is still unclear. In our study, we examined the PECAM-1 gene polymorphisms in 44 KD patients and 59 healthy children and revealed the correlation of PECAM-1 gene polymorphisms in KD children with and without coronary artery lesions (CAL). |
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PECAM-1 is a kind of cell adhesion molecule, which plays an important role in coronary artery disease. The relationship between PECAM-1 gene polymorphisms and their susceptibility to Kawasaki diseases (KD) is still unclear. In our study, we examined the PECAM-1 gene polymorphisms in 44 KD patients and 59 healthy children and revealed the correlation of PECAM-1 gene polymorphisms in KD children with and without coronary artery lesions (CAL).</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2017/2960502</identifier><identifier>PMID: 28512385</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Cardiovascular disease ; Case-Control Studies ; CD31 antigen ; Cell adhesion ; Cell adhesion & migration ; Cell adhesion molecules ; Child ; Child, Preschool ; Children ; China ; Coronary artery ; Coronary artery disease ; Coronary vessels ; Female ; Genetic polymorphisms ; Heart diseases ; Humans ; Infant ; Kawasaki disease ; Lesions ; Male ; Mucocutaneous lymph node syndrome ; Mucocutaneous Lymph Node Syndrome - genetics ; Pediatric research ; Platelet Endothelial Cell Adhesion Molecule-1 - genetics ; Polymorphism ; Polymorphism, Single Nucleotide ; Systemic vasculitis</subject><ispartof>Disease markers, 2017-01, Vol.2017 (2017), p.1-6</ispartof><rights>Copyright © 2017 Zhuoying Li et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Zhuoying Li et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Zhuoying Li et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-4137a238f56ce121a4d8d345400560c69eb326289b26ff0c1198adee25f159173</citedby><cites>FETCH-LOGICAL-c499t-4137a238f56ce121a4d8d345400560c69eb326289b26ff0c1198adee25f159173</cites><orcidid>0000-0003-0088-7564</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420431/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420431/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28512385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rennert, Gad</contributor><creatorcontrib>Tian, Lang</creatorcontrib><creatorcontrib>Chen, Jia</creatorcontrib><creatorcontrib>Jiang, Jie</creatorcontrib><creatorcontrib>Han, Dong</creatorcontrib><creatorcontrib>Li, Zhuoying</creatorcontrib><creatorcontrib>Yang, Zuocheng</creatorcontrib><title>Association of PECAM-1 Gene Polymorphisms with Kawasaki Disease in Chinese Children</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Kawasaki disease (KD) is an acute systemic vasculitis complicated by development of coronary artery lesions. PECAM-1 is a kind of cell adhesion molecule, which plays an important role in coronary artery disease. The relationship between PECAM-1 gene polymorphisms and their susceptibility to Kawasaki diseases (KD) is still unclear. In our study, we examined the PECAM-1 gene polymorphisms in 44 KD patients and 59 healthy children and revealed the correlation of PECAM-1 gene polymorphisms in KD children with and without coronary artery lesions (CAL).</description><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>CD31 antigen</subject><subject>Cell adhesion</subject><subject>Cell adhesion & migration</subject><subject>Cell adhesion molecules</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>China</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary vessels</subject><subject>Female</subject><subject>Genetic polymorphisms</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Kawasaki disease</subject><subject>Lesions</subject><subject>Male</subject><subject>Mucocutaneous lymph node syndrome</subject><subject>Mucocutaneous Lymph Node Syndrome - genetics</subject><subject>Pediatric research</subject><subject>Platelet Endothelial Cell Adhesion Molecule-1 - genetics</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Systemic vasculitis</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqNkcFvFCEUh4nR2LV682xIvJjoWB4DDFyabNZajTU2Uc-EZd50qTOwDrNu-t_Lumurnjw9Er58vB8_Qp4Cew0g5Qln0Jxwo5hk_B6ZgW5kpVXN7pMZ442uGBfsiDzK-Zox4EaYh-SIawm81nJGPs9zTj64KaRIU0cvzxbzjxXQc4xIL1N_M6RxvQp5yHQbphX94LYuu2-BvgkZXUYaIl2sQsRyLLNvR4yPyYPO9RmfHOYx-fr27MviXXXx6fz9Yn5ReWHMVAmoG1e26KTyCBycaHVbCykYk4p5ZXBZc8W1WXLVdcwDGO1aRC47kAaa-pic7r3rzXLA1mOcRtfb9RgGN97Y5IL9-yaGlb1KP6wUnIkaiuDFQTCm7xvMkx1C9tj3LmLaZAvamMZw9gt9_g96nTZjLPFsKYDpRqha3lFXrkcbYpfKu34ntXMpy_-X4Dvq1Z7yY8p5xO52ZWB21-lO2dhDpwV_9mfMW_h3iQV4uQdKD63bhv_UYWGwc3c0SM6Vqn8CVGGvrw</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Tian, Lang</creator><creator>Chen, Jia</creator><creator>Jiang, Jie</creator><creator>Han, Dong</creator><creator>Li, Zhuoying</creator><creator>Yang, Zuocheng</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0088-7564</orcidid></search><sort><creationdate>20170101</creationdate><title>Association of PECAM-1 Gene Polymorphisms with Kawasaki Disease in Chinese Children</title><author>Tian, Lang ; Chen, Jia ; Jiang, Jie ; Han, Dong ; Li, Zhuoying ; Yang, Zuocheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-4137a238f56ce121a4d8d345400560c69eb326289b26ff0c1198adee25f159173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>CD31 antigen</topic><topic>Cell adhesion</topic><topic>Cell adhesion & migration</topic><topic>Cell adhesion molecules</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>China</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary vessels</topic><topic>Female</topic><topic>Genetic polymorphisms</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Kawasaki disease</topic><topic>Lesions</topic><topic>Male</topic><topic>Mucocutaneous lymph node syndrome</topic><topic>Mucocutaneous Lymph Node Syndrome - genetics</topic><topic>Pediatric research</topic><topic>Platelet Endothelial Cell Adhesion Molecule-1 - genetics</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Systemic vasculitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tian, Lang</creatorcontrib><creatorcontrib>Chen, Jia</creatorcontrib><creatorcontrib>Jiang, Jie</creatorcontrib><creatorcontrib>Han, Dong</creatorcontrib><creatorcontrib>Li, Zhuoying</creatorcontrib><creatorcontrib>Yang, Zuocheng</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tian, Lang</au><au>Chen, Jia</au><au>Jiang, Jie</au><au>Han, Dong</au><au>Li, Zhuoying</au><au>Yang, Zuocheng</au><au>Rennert, Gad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of PECAM-1 Gene Polymorphisms with Kawasaki Disease in Chinese Children</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Kawasaki disease (KD) is an acute systemic vasculitis complicated by development of coronary artery lesions. PECAM-1 is a kind of cell adhesion molecule, which plays an important role in coronary artery disease. The relationship between PECAM-1 gene polymorphisms and their susceptibility to Kawasaki diseases (KD) is still unclear. In our study, we examined the PECAM-1 gene polymorphisms in 44 KD patients and 59 healthy children and revealed the correlation of PECAM-1 gene polymorphisms in KD children with and without coronary artery lesions (CAL).</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28512385</pmid><doi>10.1155/2017/2960502</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0088-7564</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Cardiovascular disease Case-Control Studies CD31 antigen Cell adhesion Cell adhesion & migration Cell adhesion molecules Child Child, Preschool Children China Coronary artery Coronary artery disease Coronary vessels Female Genetic polymorphisms Heart diseases Humans Infant Kawasaki disease Lesions Male Mucocutaneous lymph node syndrome Mucocutaneous Lymph Node Syndrome - genetics Pediatric research Platelet Endothelial Cell Adhesion Molecule-1 - genetics Polymorphism Polymorphism, Single Nucleotide Systemic vasculitis |
| title | Association of PECAM-1 Gene Polymorphisms with Kawasaki Disease in Chinese Children |
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