Liver X Receptor Ligands Suppress Ubiquitination and Degradation of LXRα by Displacing BARD1/BRCA1

Liver X receptor (LXR) is a ligand-activated transcription factor that plays important roles in cholesterol and lipid homeostasis. However, ligand-induced posttranslational modification of LXR is largely unknown. Here, we show that ligand-free LXRα is rapidly degraded by ubiquitination. Without liga...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2009-04, Vol.23 (4), p.466-474
Hauptverfasser:	Kim, Kang Ho, Yoon, Jeong Min, Choi, A Hyun, Kim, Woo Sik, Lee, Gha Young, Kim, Jae Bum
Format:	Artikel
Sprache:	eng
Schlagworte:	Original Research
Online-Zugang:	Volltext
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