Functional Screening of FxxLF-Like Peptide Motifs Identifies SMARCD1/BAF60a as an Androgen Receptor Cofactor that Modulates TMPRSS2 Expression

Androgen receptor (AR) transcriptional activity is tightly regulated by interacting cofactors and cofactor complexes. The best described cofactor interaction site in the AR is the hormone-induced coactivator binding groove in the ligand-binding domain, which serves as a high-affinity docking site fo...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2009-11, Vol.23 (11), p.1776-1786
Hauptverfasser:	van de Wijngaart, Dennis J, Dubbink, Hendrikus J, Molier, Michel, de Vos, Carola, Trapman, Jan, Jenster, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Cell Line Cell Line, Tumor Gene Expression Regulation Humans Male Models, Biological Original Research Peptides - chemistry Prostatic Neoplasms - metabolism Protein Structure, Tertiary Receptors, Androgen - metabolism RNA, Small Interfering - metabolism Serine Endopeptidases - metabolism Transcription Factors - chemistry Transcription Factors - metabolism Two-Hybrid System Techniques
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