Mixed Lineage Kinase-3/JNK1 Axis Promotes Migration of Human Gastric Cancer Cells following Gastrin Stimulation

Gastrin is a gastrointestinal peptide hormone, secreted by the gastric G cells and can exist as a fully processed amidated form (G17) or as unprocessed forms. All forms of gastrin possess trophic properties towards the gastrointestinal mucosa. An understanding of the signaling pathways involved is i...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2010-03, Vol.24 (3), p.598-607
Hauptverfasser:	Mishra, Prajna, Senthivinayagam, Subramanian, Rangasamy, Velusamy, Sondarva, Gautam, Rana, Basabi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracenes - pharmacology Blotting, Western Cell Line, Tumor Cell Movement - drug effects Cell Movement - genetics Enzyme Activation - drug effects Gastrins - pharmacology Humans JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - metabolism MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism Matrix Metalloproteinase 7 - genetics Mitogen-Activated Protein Kinase 8 - metabolism Mitogen-Activated Protein Kinase Kinase Kinase 11 Original Research Phosphorylation - drug effects RNA, Small Interfering Stomach Neoplasms - metabolism Stomach Neoplasms - pathology
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