Arabinosylation of recombinant human immunoglobulin-based protein therapeutics

Protein glycosylation is arguably the paramount post-translational modification on recombinant glycoproteins, and highly cited in the literature for affecting the physiochemical properties and the efficacy of recombinant glycoprotein therapeutics. Glycosylation of human immunoglobulins follows a rea...

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Veröffentlicht in:	mAbs 2017-05, Vol.9 (4), p.715-734
Hauptverfasser:	Hossler, Patrick, Chumsae, Christopher, Racicot, Christopher, Ouellette, David, Ibraghimov, Alexander, Serna, Daniel, Mora, Alessandro, McDermott, Sean, Labkovsky, Boris, Scesney, Susanne, Grinnell, Christine, Preston, Gregory, Bose, Sahana, Carrillo, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - genetics Antibody-Dependent Cell Cytotoxicity Arabinose - pharmacology CHO Cells Cricetulus Glycosylation - drug effects Humans Immunoglobulin G - blood Immunoglobulin G - chemistry Immunoglobulin G - genetics Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - genetics
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