Hyaluronan keeps mesenchymal stem cells quiescent and maintains the differentiation potential over time

Summary Hyaluronan (HA), an abundant polysaccharide found in human bodies, plays a role in the mesenchymal stem cells (MSCs) maintenance. We had previously found that HA prolonged the lifespan, and prevented the cellular aging of murine adipose‐derived stromal cells. Recently, we had also summarized...

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Veröffentlicht in:	Aging cell 2017-06, Vol.16 (3), p.451-460
Hauptverfasser:	Wong, Tzyy Yue, Chang, Chiung‐Hsin, Yu, Chen‐Hsiang, Huang, Lynn L. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipocytes - drug effects Adipocytes - metabolism anti‐aging Cell Differentiation Cell Movement - drug effects Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - metabolism Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Female Gene Expression Regulation Humans hyaluronan Hyaluronic acid Hyaluronic Acid - pharmacology Immunology lifespan Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mesenchyme Original Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Placenta - cytology Placenta - metabolism Pregnancy Primary Cell Culture Proteins quiescence Resting Phase, Cell Cycle - drug effects Resting Phase, Cell Cycle - genetics Stem cell research Stem cells Telomerase Telomerase - genetics Telomerase - metabolism
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