Oncolytic Virotherapy: A Contest between Apples and Oranges

Viruses can be engineered or adapted for selective propagation in neoplastic tissues and further modified for therapeutic transgene expression to enhance their antitumor potency and druggability. Oncolytic viruses (OVs) can be administered locally or intravenously and spread to a variable degree at...

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Veröffentlicht in:	Molecular therapy 2017-05, Vol.25 (5), p.1107-1116
Hauptverfasser:	Russell, Stephen J., Peng, Kah-Whye
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigen (tumor-associated) Antigen Presentation Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology competitive landscape Genetic Vectors - chemistry Genetic Vectors - metabolism Herpesvirus 1, Human - genetics Herpesvirus 1, Human - metabolism Humans Immune checkpoint Immunomodulation Immunotherapy Kinases Lymph nodes Lymph Nodes - immunology Lymph Nodes - pathology Lymphocytes T Macrophages Measles virus - genetics Measles virus - metabolism Melanoma Melanoma - genetics Melanoma - immunology Melanoma - pathology Melanoma - therapy Metastases Multiple Myeloma - genetics Multiple Myeloma - immunology Multiple Myeloma - pathology Multiple Myeloma - therapy Mutant Chimeric Proteins - genetics Mutant Chimeric Proteins - metabolism Oncolysis oncolytic virotherapy Oncolytic Virotherapy - methods Oncolytic Virotherapy - trends Oncolytic Viruses - genetics Oncolytic Viruses - immunology Plasmacytoma - genetics Plasmacytoma - immunology Plasmacytoma - pathology Plasmacytoma - therapy Review Skin cancer Skin Neoplasms - genetics Skin Neoplasms - immunology Skin Neoplasms - pathology Skin Neoplasms - therapy T-Lymphocytes - immunology T-Lymphocytes - pathology T-VEC Tumor cells Vaccines viro-immuno-oncology Viruses
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