Runx2 Deficiency in Mice Causes Decreased Thyroglobulin Expression and Hypothyroidism

We recently reported on the overexpression of Runx2 (Cbfa1/AML3), an osteoblast-specific transcription factor, in human papillary thyroid cancer tissues. We report here that normal thyrocytes also express Runx2 and that Runx2+/− mice are in a hypothyroid state. To clarify the mechanism, we studied t...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2010-06, Vol.24 (6), p.1267-1273
Hauptverfasser:	Endo, Toyoshi, Kobayashi, Tetsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Core Binding Factor Alpha 1 Subunit - deficiency Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism Gene Silencing Hypothyroidism - metabolism Hypothyroidism - physiopathology Male Mice Mice, Inbred C57BL Organ Specificity Original Research Promoter Regions, Genetic - genetics Protein Binding RNA, Small Interfering - metabolism Thyroglobulin - genetics Thyroglobulin - metabolism Thyroid Function Tests Thyroid Gland - growth & development Thyroid Gland - pathology Thyroid Gland - physiopathology
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