Novel Activating Mutations of the Calcium-Sensing Receptor: The Calcilytic NPS-2143 Mitigates Excessive Signal Transduction of Mutant Receptors

Abstract Context and Objective: Activating mutations in the calcium-sensing receptor (CaSR) gene cause autosomal dominant hypocalcemia (ADH). The aims of the present study were the functional characterization of novel mutations of the CaSR found in patients, the comparison of in vitro receptor funct...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2010-09, Vol.24 (9), p.1888-1888
Hauptverfasser:	Letz, Saskia, Rus, Ramona, Haag, Christine, Dörr, Helmuth-Günther, Schnabel, Dirk, Möhlig, Matthias, Schulze, Egbert, Frank-Raue, Karin, Raue, Friedhelm, Mayr, Bernhard, Schöfl, Christof
Format:	Artikel
Sprache:	eng
Schlagworte:	Translational Highlights from Jcem
Online-Zugang:	Volltext
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