Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis and Guillain-Barre Syndrome in a 16-Month-Old Child
A 16-month-old girl was diagnosed with Epstein-Barr virus hemophagocytic lymphohistiocytosis and transferred to our hospital on the 58th day of the hemophagocytic lymphohistiocytosis after treatment failure according to the Hemophagocytic Lymphohistiocytosis-2004 protocol. On admission to our hospit...
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| Veröffentlicht in: | Child neurology open 2016-01, Vol.3, p.2329048X15620641-2329048X15620641 |
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| creator | Matsui, Motohiro Shimizu, Mariko Ioi, Aya Mayumi, Azusa Higuchi, Kohei Sawada, Akihisa Sato, Maho Yasui, Masahiro Yanagihara, Keiko Inoue, Masami |
| description | A 16-month-old girl was diagnosed with Epstein-Barr virus hemophagocytic lymphohistiocytosis and transferred to our hospital on the 58th day of the hemophagocytic lymphohistiocytosis after treatment failure according to the Hemophagocytic Lymphohistiocytosis-2004 protocol. On admission to our hospital, she had a flaccid paralysis of her lower limbs. Nerve conduction studies showed a acute motor axonal neuropathy, and a diagnosis of Guillain-Barre syndrome was established. Intravenous immunoglobulin G was started on the 57th day of the Guillain-Barre syndrome. To date, her neurological recovery is incomplete. For hemophagocytic lymphohistiocytosis, after treatment failure of THP-COP regimen (pirarubicin, cyclophosphamide, vincristine, and prednisone) and 2 courses of ESCAP regimen (etoposide, prednisone, cytarabine, L-asparaginase), we are now in the process of coordinating unrelated umbilical cord blood transplantation. To the best of our knowledge, we report the youngest case of Guillain-Barre syndrome accompanied by Epstein-Barr virus hemophagocytic lymphohistiocytosis. Rapid progression of Guillain-Barre syndrome, the electrophysiological subtype of Guillain-Barre syndrome, and treatment delay possibly led to poor neurological outcome. |
| doi_str_mv | 10.1177/2329048X15620641 |
| format | Article |
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On admission to our hospital, she had a flaccid paralysis of her lower limbs. Nerve conduction studies showed a acute motor axonal neuropathy, and a diagnosis of Guillain-Barre syndrome was established. Intravenous immunoglobulin G was started on the 57th day of the Guillain-Barre syndrome. To date, her neurological recovery is incomplete. For hemophagocytic lymphohistiocytosis, after treatment failure of THP-COP regimen (pirarubicin, cyclophosphamide, vincristine, and prednisone) and 2 courses of ESCAP regimen (etoposide, prednisone, cytarabine, L-asparaginase), we are now in the process of coordinating unrelated umbilical cord blood transplantation. To the best of our knowledge, we report the youngest case of Guillain-Barre syndrome accompanied by Epstein-Barr virus hemophagocytic lymphohistiocytosis. Rapid progression of Guillain-Barre syndrome, the electrophysiological subtype of Guillain-Barre syndrome, and treatment delay possibly led to poor neurological outcome.</description><identifier>ISSN: 2329-048X</identifier><identifier>EISSN: 2329-048X</identifier><identifier>DOI: 10.1177/2329048X15620641</identifier><identifier>PMID: 28503601</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Asparaginase ; Brief Communication ; Cord blood ; Cyclophosphamide ; Cytarabine ; Epstein-Barr virus ; Etoposide ; Guillain-Barre syndrome ; Histiocytosis ; Immunoglobulin G ; Intravenous administration ; L-asparaginase ; Lymphatic diseases ; Lymphocytosis ; Nerve conduction ; Neuropathy ; Paralysis ; Prednisone ; Transplantation ; Umbilical cord ; Vincristine</subject><ispartof>Child neurology open, 2016-01, Vol.3, p.2329048X15620641-2329048X15620641</ispartof><rights>The Author(s) 2016</rights><rights>The Author(s) 2016. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2016 2016 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3071-28d5f1a487bce9880a3c861cdec1af92129f3e110fce07a912246cda30eb8e473</citedby><cites>FETCH-LOGICAL-c3071-28d5f1a487bce9880a3c861cdec1af92129f3e110fce07a912246cda30eb8e473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417294/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417294/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,21970,27857,27928,27929,44949,45337,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28503601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsui, Motohiro</creatorcontrib><creatorcontrib>Shimizu, Mariko</creatorcontrib><creatorcontrib>Ioi, Aya</creatorcontrib><creatorcontrib>Mayumi, Azusa</creatorcontrib><creatorcontrib>Higuchi, Kohei</creatorcontrib><creatorcontrib>Sawada, Akihisa</creatorcontrib><creatorcontrib>Sato, Maho</creatorcontrib><creatorcontrib>Yasui, Masahiro</creatorcontrib><creatorcontrib>Yanagihara, Keiko</creatorcontrib><creatorcontrib>Inoue, Masami</creatorcontrib><title>Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis and Guillain-Barre Syndrome in a 16-Month-Old Child</title><title>Child neurology open</title><addtitle>Child Neurol Open</addtitle><description>A 16-month-old girl was diagnosed with Epstein-Barr virus hemophagocytic lymphohistiocytosis and transferred to our hospital on the 58th day of the hemophagocytic lymphohistiocytosis after treatment failure according to the Hemophagocytic Lymphohistiocytosis-2004 protocol. 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Rapid progression of Guillain-Barre syndrome, the electrophysiological subtype of Guillain-Barre syndrome, and treatment delay possibly led to poor neurological outcome.</description><subject>Asparaginase</subject><subject>Brief Communication</subject><subject>Cord blood</subject><subject>Cyclophosphamide</subject><subject>Cytarabine</subject><subject>Epstein-Barr virus</subject><subject>Etoposide</subject><subject>Guillain-Barre syndrome</subject><subject>Histiocytosis</subject><subject>Immunoglobulin G</subject><subject>Intravenous administration</subject><subject>L-asparaginase</subject><subject>Lymphatic diseases</subject><subject>Lymphocytosis</subject><subject>Nerve conduction</subject><subject>Neuropathy</subject><subject>Paralysis</subject><subject>Prednisone</subject><subject>Transplantation</subject><subject>Umbilical cord</subject><subject>Vincristine</subject><issn>2329-048X</issn><issn>2329-048X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kcFrHCEYxYfS0IQ0956K0EsvNn6Oq-OlkC5pEtiSQ9LSm7jONzuGGZ3qTGH_-86y2zQN5KQ8f9_T5yuKd8A-ASh1zkuumah-wkJyJgW8Kk52Et1pr5_sj4uznB8YY6BKpbl8UxzzasFKyeCkGC-HPKIP9ItNifzwacr0IufovB2xJtfYx6G1m-i2o3dkte2HNrY-j36nxOwzsaEmV5PvOntwQXK3DXWKPRIfiCUg6bcYxpbedjVZtr6r3xZHje0ynh3W0-L718v75TVd3V7dLC9W1JVMAeVVvWjAikqtHeqqYrZ0lQRXowPbaA5cNyUCsMYhU1YD50K62pYM1xUKVZ4Wn_e-w7TusXYYxmQ7MyTf27Q10Xrz_0nwrdnE32YhQHEtZoOPB4MUf02YR9P77HDOGjBO2UClNYDQks3oh2foQ5xSmOMZLvj88SUoOVNsT7kUc07YPD4GmNm1ap63Oo-8fxriceBvhzNA90C2G_x364uGfwCg06sk</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Matsui, Motohiro</creator><creator>Shimizu, Mariko</creator><creator>Ioi, Aya</creator><creator>Mayumi, Azusa</creator><creator>Higuchi, Kohei</creator><creator>Sawada, Akihisa</creator><creator>Sato, Maho</creator><creator>Yasui, Masahiro</creator><creator>Yanagihara, Keiko</creator><creator>Inoue, Masami</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201601</creationdate><title>Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis and Guillain-Barre Syndrome in a 16-Month-Old Child</title><author>Matsui, Motohiro ; Shimizu, Mariko ; Ioi, Aya ; Mayumi, Azusa ; Higuchi, Kohei ; Sawada, Akihisa ; Sato, Maho ; Yasui, Masahiro ; Yanagihara, Keiko ; Inoue, Masami</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3071-28d5f1a487bce9880a3c861cdec1af92129f3e110fce07a912246cda30eb8e473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Asparaginase</topic><topic>Brief Communication</topic><topic>Cord blood</topic><topic>Cyclophosphamide</topic><topic>Cytarabine</topic><topic>Epstein-Barr virus</topic><topic>Etoposide</topic><topic>Guillain-Barre syndrome</topic><topic>Histiocytosis</topic><topic>Immunoglobulin G</topic><topic>Intravenous administration</topic><topic>L-asparaginase</topic><topic>Lymphatic diseases</topic><topic>Lymphocytosis</topic><topic>Nerve conduction</topic><topic>Neuropathy</topic><topic>Paralysis</topic><topic>Prednisone</topic><topic>Transplantation</topic><topic>Umbilical cord</topic><topic>Vincristine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsui, Motohiro</creatorcontrib><creatorcontrib>Shimizu, Mariko</creatorcontrib><creatorcontrib>Ioi, Aya</creatorcontrib><creatorcontrib>Mayumi, Azusa</creatorcontrib><creatorcontrib>Higuchi, Kohei</creatorcontrib><creatorcontrib>Sawada, Akihisa</creatorcontrib><creatorcontrib>Sato, Maho</creatorcontrib><creatorcontrib>Yasui, Masahiro</creatorcontrib><creatorcontrib>Yanagihara, Keiko</creatorcontrib><creatorcontrib>Inoue, Masami</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Child neurology open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsui, Motohiro</au><au>Shimizu, Mariko</au><au>Ioi, Aya</au><au>Mayumi, Azusa</au><au>Higuchi, Kohei</au><au>Sawada, Akihisa</au><au>Sato, Maho</au><au>Yasui, Masahiro</au><au>Yanagihara, Keiko</au><au>Inoue, Masami</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis and Guillain-Barre Syndrome in a 16-Month-Old Child</atitle><jtitle>Child neurology open</jtitle><addtitle>Child Neurol Open</addtitle><date>2016-01</date><risdate>2016</risdate><volume>3</volume><spage>2329048X15620641</spage><epage>2329048X15620641</epage><pages>2329048X15620641-2329048X15620641</pages><issn>2329-048X</issn><eissn>2329-048X</eissn><abstract>A 16-month-old girl was diagnosed with Epstein-Barr virus hemophagocytic lymphohistiocytosis and transferred to our hospital on the 58th day of the hemophagocytic lymphohistiocytosis after treatment failure according to the Hemophagocytic Lymphohistiocytosis-2004 protocol. On admission to our hospital, she had a flaccid paralysis of her lower limbs. Nerve conduction studies showed a acute motor axonal neuropathy, and a diagnosis of Guillain-Barre syndrome was established. Intravenous immunoglobulin G was started on the 57th day of the Guillain-Barre syndrome. To date, her neurological recovery is incomplete. For hemophagocytic lymphohistiocytosis, after treatment failure of THP-COP regimen (pirarubicin, cyclophosphamide, vincristine, and prednisone) and 2 courses of ESCAP regimen (etoposide, prednisone, cytarabine, L-asparaginase), we are now in the process of coordinating unrelated umbilical cord blood transplantation. To the best of our knowledge, we report the youngest case of Guillain-Barre syndrome accompanied by Epstein-Barr virus hemophagocytic lymphohistiocytosis. Rapid progression of Guillain-Barre syndrome, the electrophysiological subtype of Guillain-Barre syndrome, and treatment delay possibly led to poor neurological outcome.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>28503601</pmid><doi>10.1177/2329048X15620641</doi><oa>free_for_read</oa></addata></record> |
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| source | Sage Journals GOLD Open Access 2024; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Asparaginase Brief Communication Cord blood Cyclophosphamide Cytarabine Epstein-Barr virus Etoposide Guillain-Barre syndrome Histiocytosis Immunoglobulin G Intravenous administration L-asparaginase Lymphatic diseases Lymphocytosis Nerve conduction Neuropathy Paralysis Prednisone Transplantation Umbilical cord Vincristine |
| title | Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis and Guillain-Barre Syndrome in a 16-Month-Old Child |
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