Transforming Growth Factors α and β Are Essential for Modeling Cholangiocarcinoma Desmoplasia and Progression in a Three-Dimensional Organotypic Culture Model

To gain insight into the cellular and molecular interactions mediating the desmoplastic reaction and aggressive malignancy of mass-forming intrahepatic cholangiocarcinoma (ICC), we modeled ICC desmoplasia and progression in vitro . A unique three-dimensional (3D) organotypic culture model was establ...

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Veröffentlicht in:	The American journal of pathology 2017-05, Vol.187 (5), p.1068-1092
Hauptverfasser:	Manzanares, Miguel A, Usui, Akihiro, Campbell, Deanna J, Dumur, Catherine I, Maldonado, Gabrielle T, Fausther, Michel, Dranoff, Jonathan A, Sirica, Alphonse E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Duct Neoplasms - etiology Bile Ducts, Intrahepatic - metabolism Cholangiocarcinoma - etiology Coculture Techniques Disease Models, Animal Disease Progression Humans Karyotype Male Myofibroblasts - metabolism Pathology Rats, Inbred F344 Regular Transforming Growth Factor alpha - metabolism Transforming Growth Factor beta - metabolism Tumor Cells, Cultured
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