FOXO1 Controls Thyroid Cell Proliferation in Response to TSH and IGF-I and Is Involved in Thyroid Tumorigenesis

TSH and insulin/IGF-I synergistically induce the proliferation of thyroid cells mainly through the cAMP and phosphatidylinositol 3-kinase (PI3K) pathways. However, the events involved in this cooperative induction remain unknown, and molecules that are potentially controlled by both TSH and IGF-I ar...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2013-01, Vol.27 (1), p.50-62
Hauptverfasser:	Zaballos, Miguel A, Santisteban, Pilar
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Carcinoma - metabolism Carcinoma, Papillary Cell Line Cell Proliferation Cell Transformation, Neoplastic - metabolism Cyclic AMP - metabolism Cyclin-Dependent Kinase Inhibitor p27 - metabolism Forkhead Box Protein O1 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression Humans Insulin-Like Growth Factor I - physiology MAP Kinase Signaling System Original Research Proteasome Endopeptidase Complex - metabolism Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Rats Thyroid Cancer, Papillary Thyroid Gland - pathology Thyroid Neoplasms - metabolism Thyrotropin - physiology
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