Clustered abasic lesions profoundly change the structure and stability of human telomeric G-quadruplexes

Ionizing radiation produces clustered damage to DNA which is difficult to repair and thus more harmful than single lesions. Clustered lesions have only been investigated in dsDNA models. Introducing the term 'clustered damage to G-quadruplexes' we report here on the structural effects of m...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nucleic acids research 2017-05, Vol.45 (8), p.4294-4305
Hauptverfasser:	Kejnovská, Iva, Bednárová, Klára, Renciuk, Daniel, Dvoráková, Zuzana, Školáková, Petra, Trantírek, Lukáš, Fiala, Radovan, Vorlícková, Michaela, Sagi, Janos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - chemistry Chemical Biology and Nucleic Acid Chemistry Circular Dichroism DNA - chemistry DNA - genetics Furans - chemistry G-Quadruplexes Humans Models, Molecular Nuclear Magnetic Resonance, Biomolecular Oligonucleotides - chemistry Solutions Telomere - genetics Telomere - ultrastructure Telomere Shortening
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!