Ghrelin is a possible new predictor associated with executive function in patients with type 2 diabetes mellitus
Aims/Introduction The aim of the present research was to study the ghrelin level, executive function and their possible association in patients with type 2 diabetes mellitus. Materials and Methods A total of 370 people were recruited between March 2015 and March 2016 in this study. Among them, 212 p...
Gespeichert in:
| Veröffentlicht in: | Journal of diabetes investigation 2017-05, Vol.8 (3), p.306-313 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 313 |
|---|---|
| container_issue | 3 |
| container_start_page | 306 |
| container_title | Journal of diabetes investigation |
| container_volume | 8 |
| creator | Chen, Siting Zuo, Xuyang Li, Yuan Jiang, Tian Zhang, Nan Dai, Fang Chen, Qiaoer Zhang, Qiu |
| description | Aims/Introduction
The aim of the present research was to study the ghrelin level, executive function and their possible association in patients with type 2 diabetes mellitus.
Materials and Methods
A total of 370 people were recruited between March 2015 and March 2016 in this study. Among them, 212 participants were patients with type 2 diabetes mellitus and 158 participants were included as the control group. Their blood sample was analyzed for the level of ghrelin and other clinical indexes. Cognitive function was measured by the Montreal Cognitive Assessment, and executive function was evaluated by the Wisconsin Card Sorting Test.
Results
In the type 2 diabetes mellitus group, age, years of education, duration of diabetes, fasting blood glucose, glycated hemoglobin, hypertension and waist‐to‐hip ratio were correlated with total Montreal Cognitive Assessment scores. No association was found between ghrelin level and total Montreal Cognitive Assessment score in patients with type 2 diabetes mellitus. However, ghrelin was found to be a significant predictor for executive function impairment measured by the Wisconsin Card Sorting Test in patients with type 2 diabetes mellitus.
Conclusions
The level of serum ghrelin might be a biomarker of executive function and become a strong predictor of executive function impairment in patients with type 2 diabetes mellitus. Ghrelin might have a potential protective effect against cognitive function impairment in type 2 diabetes patients.
The level of serum ghrelin might be a biomarker of executive function and become a strong predictor of executive function impairment in patients with type 2 diabetes mellitus. Ghrelin might have a potential protective effect against cognitive function impairment in type 2 diabetic patients. |
| doi_str_mv | 10.1111/jdi.12580 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5415456</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1895103788</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4950-970b3a5501710acee083c6c2603a225202a347b7d18c9e52b1ae2639c7c33b943</originalsourceid><addsrcrecordid>eNp1kU9v1DAQxS0EolXpgS-ALHGBw7b-GzsXJFSgFFXiAmfLcWbZWWXjYDvd7rfHkLICJOYylubnpzfzCHnO2QWvdbnt8YILbdkjciqYYivOhXp8fPPmhJznvGW1pLVNY56SE2Ea20qlT8l0vUkw4EgxU0-nmDN2A9AR9nRK0GMoMVGfcwzoC_R0j2VD4R7CXPAO6HoeQ8FYv4908gVhLHlhymECKmiPvoMCme5gGLDM-Rl5svZDhvOHfka-fnj_5erj6vbz9c3V29tVUK1mq9awTnqtGTec-QDArAxNEA2TXggtmPBSmc703IYWtOi4B9HINpggZdcqeUbeLLrT3O2gD9VZ8oObEu58Orjo0f09GXHjvsU7pxXXSjdV4NWDQIrfZ8jF7TCHuoUfIc7Zcau4abWWuqIv_0G3cU5jXa9SreZMGmsr9XqhQqpnTrA-muHM_YzS1Sjdrygr--JP90fyd3AVuFyAPQ5w-L-S-_TuZpH8AY_HqM4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1895103788</pqid></control><display><type>article</type><title>Ghrelin is a possible new predictor associated with executive function in patients with type 2 diabetes mellitus</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Chen, Siting ; Zuo, Xuyang ; Li, Yuan ; Jiang, Tian ; Zhang, Nan ; Dai, Fang ; Chen, Qiaoer ; Zhang, Qiu</creator><creatorcontrib>Chen, Siting ; Zuo, Xuyang ; Li, Yuan ; Jiang, Tian ; Zhang, Nan ; Dai, Fang ; Chen, Qiaoer ; Zhang, Qiu</creatorcontrib><description>Aims/Introduction
The aim of the present research was to study the ghrelin level, executive function and their possible association in patients with type 2 diabetes mellitus.
Materials and Methods
A total of 370 people were recruited between March 2015 and March 2016 in this study. Among them, 212 participants were patients with type 2 diabetes mellitus and 158 participants were included as the control group. Their blood sample was analyzed for the level of ghrelin and other clinical indexes. Cognitive function was measured by the Montreal Cognitive Assessment, and executive function was evaluated by the Wisconsin Card Sorting Test.
Results
In the type 2 diabetes mellitus group, age, years of education, duration of diabetes, fasting blood glucose, glycated hemoglobin, hypertension and waist‐to‐hip ratio were correlated with total Montreal Cognitive Assessment scores. No association was found between ghrelin level and total Montreal Cognitive Assessment score in patients with type 2 diabetes mellitus. However, ghrelin was found to be a significant predictor for executive function impairment measured by the Wisconsin Card Sorting Test in patients with type 2 diabetes mellitus.
Conclusions
The level of serum ghrelin might be a biomarker of executive function and become a strong predictor of executive function impairment in patients with type 2 diabetes mellitus. Ghrelin might have a potential protective effect against cognitive function impairment in type 2 diabetes patients.
The level of serum ghrelin might be a biomarker of executive function and become a strong predictor of executive function impairment in patients with type 2 diabetes mellitus. Ghrelin might have a potential protective effect against cognitive function impairment in type 2 diabetic patients.</description><identifier>ISSN: 2040-1116</identifier><identifier>EISSN: 2040-1124</identifier><identifier>DOI: 10.1111/jdi.12580</identifier><identifier>PMID: 27689345</identifier><language>eng</language><publisher>Japan: John Wiley & Sons, Inc</publisher><subject>Adult ; Biomarkers - blood ; Cognitive ability ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - psychology ; Executive Function ; Female ; Ghrelin ; Ghrelin - blood ; Glucose ; Hemoglobin ; Hip ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Original</subject><ispartof>Journal of diabetes investigation, 2017-05, Vol.8 (3), p.306-313</ispartof><rights>2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd</rights><rights>2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4950-970b3a5501710acee083c6c2603a225202a347b7d18c9e52b1ae2639c7c33b943</citedby><cites>FETCH-LOGICAL-c4950-970b3a5501710acee083c6c2603a225202a347b7d18c9e52b1ae2639c7c33b943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415456/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415456/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11542,27903,27904,45553,45554,46030,46454,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27689345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Siting</creatorcontrib><creatorcontrib>Zuo, Xuyang</creatorcontrib><creatorcontrib>Li, Yuan</creatorcontrib><creatorcontrib>Jiang, Tian</creatorcontrib><creatorcontrib>Zhang, Nan</creatorcontrib><creatorcontrib>Dai, Fang</creatorcontrib><creatorcontrib>Chen, Qiaoer</creatorcontrib><creatorcontrib>Zhang, Qiu</creatorcontrib><title>Ghrelin is a possible new predictor associated with executive function in patients with type 2 diabetes mellitus</title><title>Journal of diabetes investigation</title><addtitle>J Diabetes Investig</addtitle><description>Aims/Introduction
The aim of the present research was to study the ghrelin level, executive function and their possible association in patients with type 2 diabetes mellitus.
Materials and Methods
A total of 370 people were recruited between March 2015 and March 2016 in this study. Among them, 212 participants were patients with type 2 diabetes mellitus and 158 participants were included as the control group. Their blood sample was analyzed for the level of ghrelin and other clinical indexes. Cognitive function was measured by the Montreal Cognitive Assessment, and executive function was evaluated by the Wisconsin Card Sorting Test.
Results
In the type 2 diabetes mellitus group, age, years of education, duration of diabetes, fasting blood glucose, glycated hemoglobin, hypertension and waist‐to‐hip ratio were correlated with total Montreal Cognitive Assessment scores. No association was found between ghrelin level and total Montreal Cognitive Assessment score in patients with type 2 diabetes mellitus. However, ghrelin was found to be a significant predictor for executive function impairment measured by the Wisconsin Card Sorting Test in patients with type 2 diabetes mellitus.
Conclusions
The level of serum ghrelin might be a biomarker of executive function and become a strong predictor of executive function impairment in patients with type 2 diabetes mellitus. Ghrelin might have a potential protective effect against cognitive function impairment in type 2 diabetes patients.
The level of serum ghrelin might be a biomarker of executive function and become a strong predictor of executive function impairment in patients with type 2 diabetes mellitus. Ghrelin might have a potential protective effect against cognitive function impairment in type 2 diabetic patients.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Cognitive ability</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - psychology</subject><subject>Executive Function</subject><subject>Female</subject><subject>Ghrelin</subject><subject>Ghrelin - blood</subject><subject>Glucose</subject><subject>Hemoglobin</subject><subject>Hip</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Original</subject><issn>2040-1116</issn><issn>2040-1124</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kU9v1DAQxS0EolXpgS-ALHGBw7b-GzsXJFSgFFXiAmfLcWbZWWXjYDvd7rfHkLICJOYylubnpzfzCHnO2QWvdbnt8YILbdkjciqYYivOhXp8fPPmhJznvGW1pLVNY56SE2Ea20qlT8l0vUkw4EgxU0-nmDN2A9AR9nRK0GMoMVGfcwzoC_R0j2VD4R7CXPAO6HoeQ8FYv4908gVhLHlhymECKmiPvoMCme5gGLDM-Rl5svZDhvOHfka-fnj_5erj6vbz9c3V29tVUK1mq9awTnqtGTec-QDArAxNEA2TXggtmPBSmc703IYWtOi4B9HINpggZdcqeUbeLLrT3O2gD9VZ8oObEu58Orjo0f09GXHjvsU7pxXXSjdV4NWDQIrfZ8jF7TCHuoUfIc7Zcau4abWWuqIv_0G3cU5jXa9SreZMGmsr9XqhQqpnTrA-muHM_YzS1Sjdrygr--JP90fyd3AVuFyAPQ5w-L-S-_TuZpH8AY_HqM4</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Chen, Siting</creator><creator>Zuo, Xuyang</creator><creator>Li, Yuan</creator><creator>Jiang, Tian</creator><creator>Zhang, Nan</creator><creator>Dai, Fang</creator><creator>Chen, Qiaoer</creator><creator>Zhang, Qiu</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201705</creationdate><title>Ghrelin is a possible new predictor associated with executive function in patients with type 2 diabetes mellitus</title><author>Chen, Siting ; Zuo, Xuyang ; Li, Yuan ; Jiang, Tian ; Zhang, Nan ; Dai, Fang ; Chen, Qiaoer ; Zhang, Qiu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4950-970b3a5501710acee083c6c2603a225202a347b7d18c9e52b1ae2639c7c33b943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Cognitive ability</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - psychology</topic><topic>Executive Function</topic><topic>Female</topic><topic>Ghrelin</topic><topic>Ghrelin - blood</topic><topic>Glucose</topic><topic>Hemoglobin</topic><topic>Hip</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Siting</creatorcontrib><creatorcontrib>Zuo, Xuyang</creatorcontrib><creatorcontrib>Li, Yuan</creatorcontrib><creatorcontrib>Jiang, Tian</creatorcontrib><creatorcontrib>Zhang, Nan</creatorcontrib><creatorcontrib>Dai, Fang</creatorcontrib><creatorcontrib>Chen, Qiaoer</creatorcontrib><creatorcontrib>Zhang, Qiu</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of diabetes investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Siting</au><au>Zuo, Xuyang</au><au>Li, Yuan</au><au>Jiang, Tian</au><au>Zhang, Nan</au><au>Dai, Fang</au><au>Chen, Qiaoer</au><au>Zhang, Qiu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ghrelin is a possible new predictor associated with executive function in patients with type 2 diabetes mellitus</atitle><jtitle>Journal of diabetes investigation</jtitle><addtitle>J Diabetes Investig</addtitle><date>2017-05</date><risdate>2017</risdate><volume>8</volume><issue>3</issue><spage>306</spage><epage>313</epage><pages>306-313</pages><issn>2040-1116</issn><eissn>2040-1124</eissn><abstract>Aims/Introduction
The aim of the present research was to study the ghrelin level, executive function and their possible association in patients with type 2 diabetes mellitus.
Materials and Methods
A total of 370 people were recruited between March 2015 and March 2016 in this study. Among them, 212 participants were patients with type 2 diabetes mellitus and 158 participants were included as the control group. Their blood sample was analyzed for the level of ghrelin and other clinical indexes. Cognitive function was measured by the Montreal Cognitive Assessment, and executive function was evaluated by the Wisconsin Card Sorting Test.
Results
In the type 2 diabetes mellitus group, age, years of education, duration of diabetes, fasting blood glucose, glycated hemoglobin, hypertension and waist‐to‐hip ratio were correlated with total Montreal Cognitive Assessment scores. No association was found between ghrelin level and total Montreal Cognitive Assessment score in patients with type 2 diabetes mellitus. However, ghrelin was found to be a significant predictor for executive function impairment measured by the Wisconsin Card Sorting Test in patients with type 2 diabetes mellitus.
Conclusions
The level of serum ghrelin might be a biomarker of executive function and become a strong predictor of executive function impairment in patients with type 2 diabetes mellitus. Ghrelin might have a potential protective effect against cognitive function impairment in type 2 diabetes patients.
The level of serum ghrelin might be a biomarker of executive function and become a strong predictor of executive function impairment in patients with type 2 diabetes mellitus. Ghrelin might have a potential protective effect against cognitive function impairment in type 2 diabetic patients.</abstract><cop>Japan</cop><pub>John Wiley & Sons, Inc</pub><pmid>27689345</pmid><doi>10.1111/jdi.12580</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2040-1116 |
| ispartof | Journal of diabetes investigation, 2017-05, Vol.8 (3), p.306-313 |
| issn | 2040-1116 2040-1124 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5415456 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Biomarkers - blood Cognitive ability Cross-Sectional Studies Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - psychology Executive Function Female Ghrelin Ghrelin - blood Glucose Hemoglobin Hip Humans Male Middle Aged Neuropsychological Tests Original |
| title | Ghrelin is a possible new predictor associated with executive function in patients with type 2 diabetes mellitus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T09%3A43%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ghrelin%20is%20a%20possible%20new%20predictor%20associated%20with%20executive%20function%20in%20patients%20with%20type%202%20diabetes%20mellitus&rft.jtitle=Journal%20of%20diabetes%20investigation&rft.au=Chen,%20Siting&rft.date=2017-05&rft.volume=8&rft.issue=3&rft.spage=306&rft.epage=313&rft.pages=306-313&rft.issn=2040-1116&rft.eissn=2040-1124&rft_id=info:doi/10.1111/jdi.12580&rft_dat=%3Cproquest_pubme%3E1895103788%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1895103788&rft_id=info:pmid/27689345&rfr_iscdi=true |